Recent developments of fluorescence imaging technology in the second near-infrared window  

作　　者：Shu-Tong Wu Lin Chen Wei-Wei Kang Qin Liu Meng-Ting Gao Dong-Sheng Li Yao Li Rong Dai Zi-Liang Zheng 

机构地区：[1]Institute of Medical Technology,Shanxi Medical University,Taiyuan,030001,China

出　　处：《Biomedical Engineering Communications》2022年第1期8-23,共16页生物医学工程通讯

摘　　要：Background:Fluorescence bio-imaging in the second near-infrared window(NIR-II FL,1000-1700nm)has great potential in clinical theranostics,which is of great importance providing precise locations of lesions and molecular dynamic actions simultaneously in a single nanoprobe.Methods:T here has been an upsurge of multidisciplinary research focusing on developing functional types of inorganic and organic nanoprobes that can be used for NIR-II FL with the high spatiotemporal resolution,deep tissue penetration,and negligible auto-fluorescence.Results:In this mini-review,we summarize recent progress in inorganic/organic NIR-II FL nanoprobes.We introduce the design and properties of inorganic and organic nanoprobes,in the order of single-walled carbon nanotubes,quantum dots,rare-earth-doped nanoparticles,metal nanoclusters and organic fluorophores,expect to realize precise diagnosis and efficient image-guided therapy.Conclusion:Meanwhile,to elucidate the problems and perspectives,we aim to offer diverse biological applications of inorganic/organic NIR-II FL nanoprobes and accelerate the clinical transformation progress.

关 键 词：second near-infrared biowindow NIR-II fluorescence bio-imaging organic nanoprobes inorganic nanoprobes imaging performance 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]