Targeting biosignatures of hyperglycemia and oxidative stress in diabetes comorbid depressive rats: effectiveness of hydroethanolic extract of the whole plant of Ludwigia octovalvis  

作　　者：Stuti Pandey Pawan Kumar Pandey Alakh Niranjan Sahu Himanshu Verma Manmath Kumar Nandi 

机构地区：[1]Department of Medicinal Chemistry,Faculty of Ayurveda,Institute of Medical Sciences,Banaras Hindu University,Varanasi 221005,Uttar Pradesh,India [2]Department of Pharmaceutical Engineering&Technology,Indian Institute of Technology Banaras Hindu University,Varanasi 221005,Uttar Pradesh,India

出　　处：《Traditional Medicine Research》2023年第2期13-20,共8页TMR传统医学研究

摘　　要：Background:The prime objective of the current research was to evaluate the whole plant hydroalcoholic extract of Ludwigia octovalvis(HLO)against hyperglycemia,and oxidative stress biomarkers in rats induced with diabetes comorbid depression,diabetes comorbid depression(streptozotocin-nicotinamide+electric footshocks).Methods:2,2-Diphenyl-1-picrylhydrazyl assay of HLO versus ascorbic acid was done.Effects of 200 and 400 mg/kg body weight/day HLO doses versus 25 mg/kg body weight/day metformin was studied through insulin,glucose,superoxide dismutase,lipid peroxidation,catalase,and behavioral assessment(forced swim and open field tests).Results:IC50 values of HLO and ascorbic acid were 33.52 and 27.86μg/mL respectively.Both the HLO doses showed intended results with respect to oxidative stress biomarkers in diabetes comorbid depression rats in comparison to metformin.Open field test showed better results for HLO in diabetes comorbid depression rats.However,hypoglycemic effects,and forced swim test performance of metformin was slightly higher than the 400 mg dose,followed by the 200 mg dose of HLO.Ethyl gallate,gallic acid,β-sitosterol,and quercetin in HLO might resulted in attenuating diabetic as well as depression biomarkers.Conclusion:Inhibition of glucosidase and lipase activity,and AMP-activated protein kinase phosphorylation might be the possible biochemical changes occurred in HLO treated rats.

关 键 词：2 2-diphenyl-1-picrylhydrazyl assay brain homogenate insulin superoxide dismutase content catalase activity lipid peroxidation 

分 类 号：R587.1[医药卫生—内分泌]