Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses  

作　　者：Feng-Juan Tian Jing Li Wen-Li Liu Yu-Jie Liu Yun-Jia Hu Qi-Hang Tu Yang Li Yu Bai Mang Shi Teng-Cheng Que Yan-Ling Hu Yi-Gang Tong 

机构地区：[1]College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China [2]Centre for Infection and Immunity Studies,School of Medicine,Shenzhen Campus of Sun Yat-Sen University,Sun Yat-Sen University,Shenzhen,Guangdong 518107,China [3]Faculty of Data Science,City University of Macao,Macao 999078,China [4]Guangxi Zhuang Autonomous Terrestrial Wildlife Rescue Research and Epidemic Diseases Monitoring Center,Nanning,Guangxi 530025,China [5]Life Sciences Institute,Guangxi Medical University,Nanning,Guangxi 530021,China [6]Center for Genomic and Personalized Medicine,Guangxi Medical University,Nanning,Guangxi 530021,China

出　　处：《Zoological Research》2022年第6期977-988,共12页动物学研究（英文）

基　　金：supported by the State Key Research Development Program of China(2019YFC1200500,2019YFC1200502);National Key Research and Development Program of China(2018YFA0903000,2020YFC2005405,2020YFA0712100,2020YFC0840805,2021YFC0863400);Key Project of Beijing University of Chemical Technology(XK1803-06)。

摘　　要：Previous studies have identified multiple viruses in dead or severely diseased pangolins,but descriptions of the virome in healthy pangolins are lacking.This poses a greater risk of cross-species transmission due to poor preventive awareness and frequent interactions with breeders.In this study,we investigated the viral composition of 34 pangolins with no signs of disease at the time of sampling and characterized a large number of arthropodassociated viruses belonging to 11 families and vertebrate viruses belonging to eight families,including those with pathogenic potential in humans and animals.Several important vertebrate viruses were identified in the pangolins,including parvovirus,pestivirus,and picobirnavirus.The picobirnavirus was clustered with human and grey teal picobirnaviruses.Viruses with cross-species transmission ability were also identified,including circovirus,rotavirus,and astrovirus.Our study revealed that pangolins are frequently exposed to arthropod-associated viruses in the wild and can carry many vertebrate viruses under natural conditions.This study provides important insights into the virome of pangolins,underscoring the importance of monitoring potential pathogens in healthy pangolins to prevent outbreaks of infectious diseases in domesticated animals and humans.

关 键 词：PANGOLIN Virome Arthropod-associated viruses Cross-species transmission ZOONOSES 

分 类 号：S852.65[农业科学—基础兽医学]