Th17/Treg细胞失衡参与类风湿关节炎发病机制的研究进展  

Research progress in the Th17/Treg cell imbalance involved in pathogenesis of rheumatoid arthritis

作　　者：王涛[1,2] 王钢 汪湛东 姜刚刚 漆文霞 WANG Tao;WANG Gang;WANG Zhandong;JIANG Ganggang;QI Wenxia(Gansu University of Traditional Chinese Medicine,Lanzhou 730000;University Hospital of Gansu Traditional Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2022年第11期1629-1633,共5页Chinese Journal of Osteoporosis

基　　金：国家自然基金地区项目(81960832,81860858);甘肃省科技厅青年科技基金(21JR11RA158)。

摘　　要：类风湿关节炎(rheumatoid arthritis, RA)是一种以滑膜炎和血管炎为特征的自身免疫性疾病,T淋巴细胞浸润是其发病的关键,Th17和Treg细胞具有同源性,皆由初始CD4~+T细胞分化而来。其中Th17细胞促进炎症反应,而Treg细胞抑制炎症反应,维持自身免疫耐受。RA的发生与免功能疫紊乱、免疫细胞过渡活化以及免疫细胞亚群比例失衡密切相关。Th17/Treg失衡存在整个RA疾病过程中,最终导致滑膜炎症、关节破坏、骨侵蚀等,加重RA病程的发展。调节Th17/Treg之间的平衡是治疗RA的一个靶点。笔者将对Th17/Treg失衡在RA发生发展中的调节作用进行综述。Rheumatoid arthritis(RA) is an autoimmune disease characterized by synovitis and vasculitis. T lymphocyte infiltration is the key to its pathogenesis. Th17 and Treg cells are homologous, and both are differentiated from initial CD4T cells. Among them, Th17 cells promote inflammatory response, while Treg cells inhibit inflammatory response and maintain autoimmune tolerance. The occurrence of RA is closely related to the disorder of immune disease, the over-activation of immune cells, and the imbalance of the proportion of immune cell subsets. Th17/Treg imbalance exists in the entire RA disease process, ultimately leading to synovial inflammation, joint destruction, bone erosion, etc., aggravating the course of RA. Regulation of Th17/Treg balance is a target for the treatment of RA. This paper reviews the regulatory role of Th17/Treg imbalance in the occurrence and development of RA.

关 键 词：TH17细胞 TREG细胞 类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]