异补骨脂素调节骨代谢的研究进展  

Research progress of the effect of isopsoralen on bone metabolism

作　　者：刘雨昕 孟明星 周茜[1] 徐红丹 张博[3] 李微 LIU Yuxin;MENG Mingxing;ZHOU Xi;XU Hongdan;ZHANG Bo;LI Wei(Hubei University of Arts and Science,Xiangyang 441053,China;Wuxi Higher Health Vocational Technology College,Wuxi 214028,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]湖北文理学院医学部,湖北襄阳441053 [2]无锡卫生高等职业技术学院,江苏无锡214028 [3]黑龙江中医药大学中医药研究院,黑龙江哈尔滨150040

出　　处：《中国骨质疏松杂志》2022年第11期1674-1677,共4页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金面上项目(81873108);国家自然科学基金青年项目(82003975,82205234);湖北省襄阳市科技局项目(2020ZD22,2022YL07A);湖北省博士科研启动经费资助项目(2059041);湖北文理学院学科开放基金项目(xk2020059);湖北文理学院大学生创新创业项目(S202210519008,X202210519147,X202210519076,X202210519150,X202110519042,X202110519084)。

摘　　要：异补骨脂素作为补肾药物补骨脂(Psoralea corylifolia Linn)的有效活性成分之一,是补骨脂发挥多种药理作用的主要药效成分。祖国医学依据“肾主骨”理论,将很多补肾药用于骨骼系统疾病的治疗。异补骨脂素是具有补肾活性的中药单体,其在骨代谢的领域被广泛研究。本文将近年来异补骨脂素在骨病领域的基础研究及临床应用进行综述,为阐明异补骨脂素调节骨代谢的机制提供便利。Isopsoralen is the main pharmacodynamic component of Psoralea corylifolia Linn. In the field of Traditional Chinese medicine, many tonifying kidney drugs are used to treat bone diseases based on the theory of "Kidney Governing Bones". Isopsoralen as a traditional Chinese medicine extract monomer with tonifying kidney activity which has been widely studied in the field of bone metabolism. In this paper, the basic research and clinical application of isopsoralen in bone diseases in recent years were reviewed. It is hoped that this paper can provide convenience for clarifying the mechanism of isopsoralen regulating bone metabolism.

关 键 词：异补骨脂素 骨代谢 肾主骨 

分 类 号：R589.[医药卫生—内分泌]