Multi-feature weight factor extraction and survival risk assessment of hepatocellular carcinoma based on a clinical missing dataset-independent support vector machine  

作　　者：Fumin Wang Nan Zhang Xiaoning Wu Wei Zhang Qiang Lu Rongqian Wu Xu-Feng Zhang Hui Guo Yi Lv 

机构地区：[1]Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,China [2]Department of Medical Oncology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,China

出　　处：《iLIVER》2022年第3期154-158,共5页国际肝胆健康（英文）

基　　金：supported by the National Nature Science Foundation of China(grant nos.11534008,11804271,and 91736104);the Ministry of Science and Technology of China(2016YFA0301404);the China Postdoctoral Science Foundation via project no.2020M673366;the foundation of the First Affiliated Hospital of Xi'an Jiaotong University no.2021QN-15.In addition,Yi Lv acknowledges support from the National Key R&D Project of China(nos.2018YFC0115300 and 2018YFC0115305,YL);the National Natural Science Foundation of China(no.81727802);the Innovation Capacity Support Plan of Shaanxi Province(no.2020TD-040,RW).

摘　　要：Background:In clinical datasets,the characteristics of an individual patient vary so much that data loss becomes a normal event,which may be a unignorable dilemma in clinical data analysis.Therefore,the construction of a machine learning model aimed at missing clinical datasets(MCD)is of great clinical importance.Methods:All included patients were divided into two groups according to outcome within a period of up to 36 months or less.The following characteristics(variables)were collected:age,sex,Child-Pugh status,hepatitis status,cirrhosis status,treatment,tumor size,portal vein tumor thrombus,and alpha fetoprotein(μg/mL),and a missing dataset-independent support vector machine(MDI-SVM)independent of missing data was built for the analysis.Results:A MCD-independent SVM was developed based on clinical data from 1334 patients with hepatocellular carcinoma(HCC)at a single center,which had an accuracy of 84.43%in the survival analysis in the presence of 5%missing data.Based on the different combinations of features,our model calculated five features(tumor size,age,treatment,hepatitis status,and alpha fetoprotein)that had the greatest impact on survival in patients with HCC and extracted their weighting factors.Conclusions:A MCD-independent SVM was developed to achieve prognosis prediction for patients with HCC in the absence of first-visit data.

关 键 词：Machine learning HCC MDI-SVM 

分 类 号：R735.7[医药卫生—肿瘤]