间充质干细胞治疗严重烫伤诱导的肝脏损伤研究进展  

Research Progress of Mesenchymal Stem cells in the treatment of severe burn⁃induced Hepatic injury

作　　者：林卉 庞荣清 LIN Hui;PANG Rongqing(Stem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions,Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province,Kunming Key Laboratory of Stem Cell and Regenerative Medicine,Basic Medical Laboratory,920 Hospital of Joint Logistics Support Force of Chinese PLA,Yunnan Province,Kunming 650032,China)

机构地区：[1]中国人民解放军联勤保障部队第九二〇医院干细胞与免疫细胞生物医药技术国家地方联合工程实验室、云南省细胞治疗技术转化医学重点实验室、昆明市干细胞与再生医学重点实验室、基础医学实验室,昆明650032

出　　处：《实用医学杂志》2022年第20期2630-2634,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金面上项目(编号:31970515);联勤保障部队第九二〇医院院内科技计划项目(编号:2019YGA05)。

摘　　要：烫伤是一种创伤后炎症性疾病,多器官衰竭是烫伤后死亡的主要原因,过度的全身和局部炎症直接导致终末器官损伤。肝脏是人体最大的代谢和解毒器官,极易遭受内毒素的攻击,肝功能的恶化会导致烫伤患者的发病率和死亡率增高,因此严重烫伤后肝损伤的修复意义重大。尽管烫伤的临床管理取得了显著进展,但目前严重烫伤的治疗仍有较大的局限性。近年来,间充质干细胞治疗在组织修复方面有很大的希望,本综述将重点研究间充质干细胞在烫伤诱导的肝脏损伤方面的作用。Burn is a post⁃traumatic inflammatory disease.Multiple organ failure is the main cause of death after burn.Excessive systemic and local inflammation directly leads to terminal organ injury.Liver is the largest metabolic and detoxification organ of the human body,and it is easy to be attacked by endotoxin.The deterioration of liver function will lead to increased morbidity and mortality of burn patients.Therefore,the repair of hepatic injury after severe burn is of great significance.Although progress has been made in the clinical management of burns,there are still limitations in the treatment of severe burns.In recent years,Mesenchymal stem cells(MSCs)have shown great promise in tissue repair.In this review,we will focus on the role of MSCs in severe burn⁃induced hepatic injury.

关 键 词：间充质干细胞 烫伤 肝脏 

分 类 号：S853.441[农业科学—临床兽医学]