3-(3,5-二叔丁基-4-羟基苯基)丙酸甲酯的叔丁醇钾催化合成  

Synthesis of Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)Catalyzed by Potassium Tert-Butanol

作　　者：徐文琳 李巧云 肖林久[1,2] 李文泽 XV Wen-lin;LI Qiao-yun;XIAO Lin-jiu;LI Wen-ze(College of Science,Shenyang University of Chemical Technology,Shenyang Liaoning 110142,China;Key Laboratory of Rare Earth Chemistry and Application of Liaoning Province,Shenyang Liaoning 110142,China;Liaoning Huaxing Daily Chemical Industry Technology Research Institute Limited Company,Dengta Liaoning province 111399,China)

机构地区：[1]沈阳化工大学理学院,辽宁沈阳110142 [2]辽宁省稀土化学及应用重点实验室,辽宁沈阳110142 [3]辽宁华星日化产业技术研究院有限公司,辽宁灯塔111399

出　　处：《当代化工》2022年第9期2146-2149,共4页Contemporary Chemical Industry

基　　金：辽宁省科技攻关专项(项目编号:2021JH1/10400063)。

摘　　要：以叔丁醇钾为催化剂,通过2,6-二叔丁基苯酚与丙酸甲酯进行迈克尔加成反应制备3-(3,5-二叔丁基-4-羟基苯基)丙酸甲酯。考察了反应温度、物料配比、催化剂用量、反应时间等因素对反应的影响,确定较适宜的反应条件。结果表明:以叔丁醇钾为催化剂,2,6-二叔丁基苯酚与丙烯酸甲酯投料比为1∶1.2(物质的量之比),催化剂用量为2%,在130℃反应1 h,2,6-二叔丁基苯酚转化率可达99%以上,产品产率达97%以上。Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)was synthesized through Michael addition reaction of 2,6-di-tert-butyl-phenol and acrylic acid methyl ester using potassium tert-butanol as catalyst.The optimal experimental conditions,such as reaction temperature,material ratio,reaction time and catalyst dosage were determined by using the method of single factor analysis.With potassium tert-butanol as catalyst,the feed ratio of 2,6-di-tert-butyl-phenol and acrylic acid methyl ester was 1∶1.2(molar ratio of material),the amount of catalyst was 2%,and the reaction was carried out at 130℃for 1 h.The final conversion rate reached 99%and the yield reached 97%.

关 键 词：2 6-二叔丁基苯酚 丙烯酸甲酯 加成反应 抗氧剂 

分 类 号：TQ31.2[化学工程—高聚物工业]