白细胞介素-37在冠心病发生及发展进程中作用的研究进展  

Role of interleukin-37 in occurrence and development of coronary heart disease

作　　者：王林[1] 丛洪良[1] 陈康寅[2] 陶华岳[2] WANG Lin;CONNG Hongliang;CHEN Kangyin;TAO Huayue(x09Tianjin Chest Hospital,Tianjin 300222,China;The Second Hospital,Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津市胸科医院,天津300222 [2]天津医科大学第二医院,天津300211

出　　处：《现代医院》2022年第11期1791-1794,共4页Modern Hospitals

基　　金：天津市科技计划项目(18ZXRHSY00180)。

摘　　要：白细胞介素-37(IL-37)是一种新型的抗炎因子,是IL-1家族最新成员之一,具有介导免疫炎性反应的作用,在多种炎性反应以及免疫疾病发生与进展中起着重要作用。IL-37通过抑制促炎因子的生成,通过调节血脂、激活NF-κB以及免疫应答实现其在炎症性疾病与免疫性疾病中保护性作用。IL-37主要表达于机体冠状动脉与动脉粥样硬化斑块,在冠心病的发生与发展进程中发挥重要作用,本研究证实IL-37是评估冠心病患者预后的重要的指标,在预防冠心病发生、发展中具有重要意义。Interleukin-37(IL-37),one of the latest-discovered members of the IL-1 family,is a new type of anti-inflammatory factor.It has been found to play a role not only in mediating the immune inflammatory response,but also in triggering and facilitating a variety of inflammatory reactions and immune diseases.Il-37 plays a protective role in inflammatory and immune diseases by inhibiting the production of pro-inflammatory factors,regulating blood lipid,and activating NF-κB and immune responses.It is even proved to function in the occurrence and development of coronary heart disease by expressing in foam cells of coronary arteries and atherosclerotic plaques.This study confirms that IL-37 is an important indicator for evaluating the prognosis of patients with coronary heart disease,and it is of great significance in preventing the occurrence and development of coronary heart disease.

关 键 词：白细胞介素-37 冠心病 炎症反应 研究进展 

分 类 号：R541.4[医药卫生—心血管疾病]