胚胎植入前单基因遗传学检测辅助助孕妊娠结局的影响因素分析  

Analysis of influencing factors on pregnancy outcome of PGT-M assisted pregnancy

作　　者：赵琴[1] 王格[1] 蔡桂丰[1] ZHAO Qin;WANG Ge;CAI Guifeng(Zhuhai Maternal and Child Health Hospital,Zhuhai 519000,China)

机构地区：[1]珠海市妇幼保健院,广东珠海519000

出　　处：《现代医院》2022年第11期1795-1797,共3页Modern Hospitals

基　　金：广东省医学科学技术研究基金(A2022466);珠海市科技计划医疗项目(ZH22036201210170PWC)。

摘　　要：目的探讨胚胎植入前单基因遗传学检测(PGT-M)辅助助孕妊娠结局的影响因素。方法选择2020年1月10日—2021年11月28日因单基因疾病在医院生殖医学中心接受胚胎植入前遗传性检测(PGT)助孕患者33例作为研究对象,对该不孕不育患者的一般资料、病历资料、染色体检查数据进行收集和分析,采用单因素和多因素回归分析的方式研究单基因病检测(PGT-M)周期辅助助孕对于不孕不育患者妊娠结局的影响。结果接受胚胎植入前单基因遗传学检测(PGT-M)周期辅助助孕的不孕不育患者中有8例患者成功妊娠,妊娠率为24.24%;单因素分析显示,未成功妊娠组和成功妊娠组病因、染色体比较,差异有统计学意义(P<0.05);两组年龄、胚囊评分比较,差异无统计学意义(P>0.05);多因素回归分析显示,不孕不育患者染色体情况与患者病因是PGT-M辅助助孕妊娠结局的影响因素(P<0.05)。结论通过多因素的分析完成PGT-M辅助助孕妊娠结局,能够有效地根据相应的风险指标对于保证良好的妊娠结局可以有更好的预防和干预作用。Objective To explore the multiple factors affecting the outcome of PGT-M assisted pregnancy.Methods From January 10,2020 to November 28,2021,33 infertile patients with single gene disease in our hospital received preimplantation genetic testing(PGT)as the research object,and their general information,medical records and chromosome examination data were collected and analyzed.Using univariate and multivariate regression analysis to study the detection of monogenic diseases Effect of PGT-M on pregnancy outcome in infertile women.Results There were 8 successful pregnancies in the PGT-M group,and the pregnancy rate was 24.24%.Univariate analysis showed that there were significant differences in etiology and chromosome between the unsuccessful pregnancy group and the successful pregnancy group(P<0.05);There was no significant difference in age and embryo sac score between the two groups(P>0.05).Multivariate regression analysis showed that the chromosome status and etiology of infertility patients were the influencing factors of PGT-M assisted pregnancy outcome(P<0.05).Conclusion Through the analysis of multiple factors to complete PGT-M assisted pregnancy outcome,can effectively according to the corresponding risk indicators to ensure a good pregnancy outcome can have a better role in prevention and intervention.

关 键 词：PGT-M助孕 妊娠结局 多因素 

分 类 号：R714.5[医药卫生—妇产科学] R596.2[医药卫生—临床医学]