胆碱能抗炎通路α7烟碱型乙酰胆碱受体的最新研究进展  

The latest research progress ofα7 nicotinic acetylcholine receptor in cholinergic anti-inflammatory pathway

作　　者：张慧敏 向科发 史小飞 秦臻 刘霞 ZHANG Huimin;XIANG Kefa;SHI Xiaofei;QIN Zhen;LIU Xia(Department of Clinical Pharmacy,School of Pharmacy,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学药学院临床药学教研室,上海200433

出　　处：《药学实践与服务》2022年第6期485-493,共9页Journal of Pharmaceutical Practice and Service

基　　金：国家自然科学基金项目(82073842,81773726);上海市2021年度“科技创新行动计划”优秀学术/技术带头人计划项目(21XD1404700)。

摘　　要：α7nAChR(α7 nicotinic acetylcholine receptor)属于烟碱型乙酰胆碱受体(nAChRs),是机体胆碱能抗炎通路的关键受体,在免疫系统的神经调控中发挥重要作用。近期研究发现,α7nAChR还参与调节免疫以外的多种生理病理过程,如非酒精性脂肪肝、血管新生、保护心脏等。此外,α7nAChR在神经退行性疾病等与能量代谢紧密关联。本文综述α7nAChR在治疗炎症、改善能量代谢中发挥的作用,以及α7nAChR参与治疗的新方向。α7 nicotinic acetylcholine receptor(α7nAChR)belongs to nicotinic acetylcholine receptors(nAChRs),which is the key receptor in cholinergic anti-inflammatory pathway and plays an important role in the neural regulation of immune system.Recent studies have found thatα7nAChR is also involved in the regulation of various physiological and pathological processes other than immunity,such as non-alcoholic fatty liver,angiogenesis,heart protection,etc.In addition,α7nAChR is closely related to energy metabolism in neurodegenerative diseases.This article reviews the role ofα7nAChR in treating inflammation and improving energy metabolism,and the new direction ofα7nAChR involved in therapy.

关 键 词：Α7烟碱型乙酰胆碱受体 胆碱能抗炎通路 能量代谢 线粒体 神经退行性疾病 

分 类 号：R967[医药卫生—药理学]