和化法治疗老年慢性稳定性心绞痛临床观察  

Effects of harmonizing method on senile patients with chronic stable angina pectoris

作　　者：张露露[1] 张其慧[1] 石玥 ZHANG Lu-lu;ZHANG Qi-hui;SHI Yue(Internal Department of TCM,Huguosi TCM Hospital Afiliated to the Bejing University of Chinese Medicine,Bejing 100035,China)

机构地区：[1]北京中医药大学附属护国寺中医医院中医内科,北京100035

出　　处：《北京中医药》2022年第8期917-920,共4页Beijing Journal of Traditional Chinese Medicine

基　　金：许彭龄全国名老中医药专家传承工作室项目(2011-sz-c-35)。

摘　　要：目的 观察和化法治疗老年慢性稳定性心绞痛的临床疗效。方法 将64例老年慢性稳定性心绞痛患者随机分为2组,对照组给予常规治疗,治疗组在对照组的基础上加用具有和化宣痹作用的中药汤剂口服,2次/d,2组疗程均为8周。比较2组治疗前后临床疗效、心肺运动功能、硝酸甘油用量及安全性。结果 治疗后,治疗组症状总有效率高于对照组(P<0.05)。2组心电图总有效率比较差异无统计学意义(P>0.05)。与治疗前比较,治疗组最大氧脉搏(VO/HR)、峰值氧耗量(PeakVO)、无氧域(AT)及最大运动时间均有升高,差异有统计学意义(P<0.05);对照组VO/HR、AT较治疗前升高,差异有统计学意义(P<0.05),PeakVO及最大运动时间与治疗前比较,差异无统计学意义(P>0.05);治疗组VO/HR、PeakVO、AT均高于对照组,差异有统计学意义(P<0.05),2组最大运动时间比较,差异无统计学意义(P>0.05)。治疗组硝酸甘油停减率高于对照组,差异有统计学意义(P<0.05)。2组均未见明显不良反应。结论 和化法治疗老年慢性稳定性心绞痛,可显著改善患者临床症状,提高心肺运动功能及硝酸甘油减停率,且安全性高。Objective To explore the curative effects of harmonizing method of traditional Chinese medicine on senile patients with chronic stable angina pectoris.Methods 64 cases of senile patients with chronic stable angina pectoris were randomly divided into two groups.The control group was treated by baseline treatment.The treatment group was treated by Chinese herbal medicines with harmonizing and relieving paralysis actions on the basis of the control group.Both groups were treated twice daily,and the treatment course was 8 weeks.The clinical efficacy, cardiopulmonary exercise function, nitroglycerin consumption and safety of two groups were compared before and after treatment.Results After treatment,the total effective rate of symptoms in the treatment group was higher than that in the control group(P<0.05).There was no statistical difference in the total effective rate of ECG between the two groups(P>0.05).The oxygen pulse max(VO/HR),peak oxygen uptake(Peak VO),AT,max exercise time in treatment group after the treatment were significantly improved than those before the treatment(P<0.05) with the difference statistically significant(P<0.05);VO/HR/HRand AT increased after the treatment in control group with the difference statistically significant(P<0.05),while there was no statistical difference on Peak VOand max exercise time after the treatment(P>0.05).VO/HR,Peak VOand AT in the treatment group were higher than those in the control group(P<0.05) with the difference statistically significant.There was no significant difference in maximum exercise time between the two groups(P>0.05).The stopping rate of nitroglycerin in treatment group was higher than that in control group, and the difference was statistically significant(P<0.05).There was no adverse reactions in two groups during treatment.Conclusion TCM Harmonizing method used for senile patients with chronic stable angina pectoris is safe and effective in improving clinical symptoms, enhancing cardiopulmonary function and nitroglycerin stopping rate.

关 键 词：和化宣痹 慢性稳定性心绞痛 心肺运动试验 老年人 

分 类 号：R541.4[医药卫生—心血管疾病]