由β,γ-不饱和α-酮酸甲酯合成氘代肉桂醛的工艺研究  

Efficient Preparation of Deuterated Cinnamaldehyde fromβ,γ-Unsaturatedα-Methyl Ketoate

作　　者：张文轩 吕健 Zhang Wenxuan;Lyu Jian(School of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao 266011,China)

机构地区：[1]青岛科技大学化学与分子工程学院,山东青岛266011

出　　处：《山东化工》2022年第20期5-8,共4页Shandong Chemical Industry

摘　　要：由于氘代分子在各类科学研究中有着旺盛的需求,因此开发新的策略以合成各类氘代分子受到了广泛地关注。本论文以β,γ-不饱和α-酮酸甲酯为原料,在温和的条件下仅一步反应就能够以高达84%的收率和98%的氘代率高效制备氘代肉桂醛。此方法避免了昂贵氘代试剂及催化剂的使用,具有很高的原子经济性和潜在的应用价值。Because of the high demand for d-labelled molecules in the scientific research fields,many efforts have been devoted to developing a new method for the synthesis of d-labelled molecules.In this paper,we developed a new method that deuterated cinnamaldehyde can be efficiently prepared usingβ,γ-unsaturatedα-methyl ketoate with only one step under mild conditions,avoid the use of expensive deuterated reagents and catalysts,with high atom economy and potential application in industrial production.

关 键 词：氘代反应 肉桂醛 β γ-不饱和α-酮酸甲酯 原子经济性 

分 类 号：O626.32[理学—有机化学]