妊娠期高血压病病人RDW⁃CV、NLR、MLR、PLR与血栓弹力图的相关性分析  

Correlation analysis of RDW⁃CV,NLR,MLR,PLR and thromboelasmography of patients with hypertensive disorders complicating pregnancy

作　　者：郭婷 杨晓丽 田珏 杨贵芳 刘芳 李雪敏 GUO Ting;YANG Xiaoli;TIAN Jue;YANG Guifang;LIU Fang;LI Xuemin(Shanxi Medical University,Shanxi 030001 China)

机构地区：[1]山西医科大学,山西030001 [2]山西医科大学第九临床医学院

出　　处：《护理研究》2022年第22期3963-3967,共5页Chinese Nursing Research

基　　金：山西省医学重点科研项目计划重大科技攻关专项课题,编号:2020XM09;山西省应用基础研究计划项目,编号:201901D111461,201901D111201;山西省省筹资金资助回国留学人员科研项目,编号:2021⁃175。

摘　　要：目的:探讨妊娠期高血压病(HDCP)病人红细胞分布宽度变异系数(RDW⁃CV)、中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)、单核细胞淋巴细胞比值(MLR)与血栓弹力图各指标的相关性。方法:选取2020年3月1日—2021年3月1日在太原市中心医院产科住院的103例妊娠妇女作为研究对象,将31例HDCP病人设为病例组,将72例正常妊娠妇女设为对照组。比较两组慢性炎症指标及血栓弹力图,分析病例组炎症指标与血栓弹力图各指标的相关性。结果:病例组中性粒细胞(NEU)为(6.89±2.30)×10^(9)/L,单核细胞(MON)为(1.86±3.52)×10^(9)/L,RDW⁃CV为(20.07±13.37)%,均高于对照组[NEU为(5.61±3.15)×10^(9)/L,MON为(0.47±0.15)×10^(9)/L,RDW⁃CV为(14.62±2.62)%];病例组PLR为132.73(97.62,172.67),低于对照组[190.97(108.72,242.24)];病例组30 min血凝块溶解百分数(LY30)为(0.44±0.49)%,血凝块溶解预估百分比(EPL)为(0.44±0.49)%,均低于对照组[LY30为(1.92±0.77)%,EPL为(1.92±0.77)%],差异均有统计学意义(P<0.05)。相关性分析结果显示,病例组炎症指标RDW⁃CV、NLR与LY30、EPL呈负相关(P<0.05),PLR、MLR与LY30、EPL相关性不明显(P>0.05)。结论:在HDCP病人中,炎性指标RDW⁃CV可能对其纤溶抑制有一定预测作用,可作为HDCP发生、发展的临床监测指标。Objective:To investigate correlation analysis of coefficient of variation of red cell distribution width(RDW⁃CV),neutrophil⁃lymphocyte ratio(NLR),platelet⁃lymphocyte ratio(PLR),monocyte⁃lymphocyte ratio(MLR)and indexes of thromboelasmography of patients with hypertensive disorders complicating pregnancy(HDCP).Methods:103 pregnant women hospitalized in obstetrics department of Taiyuan Central Hospital from March 1,2020 to March 1,2021 were selected as research subjects.31 HDCP patients were set as case group,and 72 normal pregnant women were set as control group.The chronic inflammatory indexes and thromboelasmography of the two groups were compared,and correlation between inflammatory indexes and indexes of thromboelastogram of the case group was analyzed.Results:In case group,neutrophil(NEU)was(6.89±2.30)×10^(9)/L,monocytes(MON)was(1.86±3.52)×10^(9)/L and RDW⁃CV was(20.07±13.37)%,all were higher than those in control group[NEU was(5.61±3.15)×10^(9)/L,MON was(0.47±0.15)×10^(9)/L,RDW⁃CV was(14.62±2.62)%].In case group,PLR was 132.73(97.62,172.67),lower than that in control group[190.97(108.72,242.24)].In case group,percent lysis 30 min after MA(LY30)was(0.44±0.49)%and estimate percent lysis(EPL)was(0.44±0.49)%,lower than those in control group[LY30 was(1.92±0.77)%,EPL was(1.92±0.77)%],the difference was statistically significant(P<0.05).The results of correlation analysis showed that inflammatory indicators such as RDW⁃CV and NLR were negatively correlated with LY30 and EPL in case group(P<0.05),while PLR and MLR were not significantly correlated with LY30 and EPL in case group(P>0.05).Conclusions:Among HDCP patients,the inflammatory index such as RDW⁃CV may have certain predictive effect on fibrinolysis inhibition,which can be used as clinical monitoring index for occurrence and development of HDCP.

关 键 词：妊娠期高血压病 红细胞分布宽度 中性粒细胞淋巴细胞比值 血小板淋巴细胞比值 单核细胞淋巴细胞比值 血栓弹力图 相关性 护理 

分 类 号：R714.246[医药卫生—妇产科学]