血清胆红素、C反应蛋白、载脂蛋白A1在糖尿病足患者中的表达及诊断价值  

Expression and diagnostic value of serum bilirubin,C-reactive protein and apolipoprotein A1 in diabetic foot patients

作　　者：葛俐娜[1] GE Li′na(General Practice,the Fourth Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330002,China)

机构地区：[1]南昌大学第四附属医院全科医学,江西南昌330002

出　　处：《中国当代医药》2022年第32期58-61,共4页China Modern Medicine

基　　金：江西省卫生计生委科技计划项目(20155375)。

摘　　要：目的探讨血清胆红素、C反应蛋白(CRP)、载脂蛋白A1(APO-A1)水平在糖尿病足(DF)患者中的表达及诊断价值。方法选取2021年2月至2022年2月南昌大学第四附属医院收治的96例糖尿病患者作为研究对象,按照是否并发DF将纳入对象分为DF组(n=48)与非DF组(n=48)。采集患者的外周静脉血,检测并比较两组患者的总胆红素(TBil)、直接胆红素(DBil)、间接胆红素(IBil)、CRP、APO-A1表达水平,采用Pearson分析DF病情程度与TBil、IBil、CRP、APO-A1的相关性,并作受试者工作特征(ROC)曲线分析不同指标对DF的诊断价值。结果两组患者的DBil水平比较,差异无统计学意义(P>0.05);DF组患者的CRP水平高于非DF组,差异有统计学意义(P<0.05)。DF组患者的TBil、IBil、APO-A1水平低于非DF组,差异有统计学意义(P<0.05)。Pearson分析结果显示,DF病情程度与TBil、IBil、CRP、APO-A1呈正相关(r=0.302、0.302、0.982、0.469,P<0.05)。TBil诊断DF的灵敏度为100.00%,特异度为83.10%;IBil诊断DF的灵敏度为83.30%,特异度为60.40%;CRP诊断DF的灵敏度为97.90%,特异度为100.00%;APO-A1诊断DF的灵敏度为85.40%,特异度为27.10%;TBil、IBil、CRP、APO-A1指标联合诊断DF的灵敏度为100.00%,特异度为95.23%,曲线下面积为0.998。TBil、IBil、CRP、APO-A1指标联合检测的灵敏度高于IBil、APO-A1指标单独诊断,特异度高于IBil、APO-A1、TBil指标单独诊断,差异有统计学意义(P<0.05)。结论胆红素、CRP在DF患者中具有较高的表达水平,APO-A1表达水平较低,而胆红素、CRP、APO-A1联合检测在DF中具有较高的诊断价值。Objective To explore the expression and diagnostic value of serum bilirubin,C-reactive protein(CRP),and apolipoprotein A1(APO-A1)levels in patients with diabetic foot(DF).Methods A total of 96 diabetic patients admitted to the Fourth Affiliated Hospital of Nanchang University from February 2021 to February 2022 were selected as the research objects.According to whether they were complicated with DF,the included subjects were divided into DF group(n=48)and non-DF group(n=48).Peripheral venous blood was collected from the patients,and the expression levels of total bilirubin(TBil),direct bilirubin(DBil),indirect bilirubin(IBil),CRP and APO-A1 were detected and compared between the two groups.Pearson was used to analyze the correlation between the severity of DF and TBil,IBil,CRP,APO-A1.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of different indexes for DF.Results There was no significant difference in DBil level between the two groups(P>0.05).The CRP level of DF group was higher than that of non-DF group,and the difference was statistically significant(P<0.05).The levels of TBil,IBil and APO-A1 in DF group were lower than those in non-DF group,and the differences were statistically significant(P<0.05).Pearson analysis showed that the severity of DF was positively correlated with TBil,IBil,CRP,APO-A1(r=0.302,0.302,0.982,0.469,P<0.05).The sensitivity and specificity of TBil in diagnosing DF were 100.00%and 83.10%,respectively.The sensitivity and specificity of IBil in diagnosing DF were 83.30%and 60.40%,respectively.The sensitivity and specificity of CRP in the diagnosis of DF were 97.90%and 100.00%,respectively.The sensitivity and specificity of APO-A1 in diagnosing DF were 85.40%and 27.10%,respectively.The sensitivity,specificity and area under the curve of TBil,IBil,CRP and APO-A1 in the combined diagnosis of DF were 100.00%,95.23%and 0.998,respectively.The sensitivity of combined detection of TBil,IBil,CRP and APO-A1 indicators was higher than that of IBil and APO-A1

关 键 词：胆红素 C反应蛋白 载脂蛋白A1 糖尿病足 表达水平 

分 类 号：R587.1[医药卫生—内分泌]