血清氨基末端B型脑钠肽前体、前白蛋白、白细胞介素-32、白细胞介素-6在伴肺部感染急性心肌梗死早期诊断和预后评估中的临床意义  

Clinical significance of serum N-terminal pro B-type brain natriuretic peptide,prealbumin,interleukin-32 and interleukin-6 in early diagnosis and prognosis of acute myocardial infarction with pulmonary infection

作　　者：冯徐俊[1] FENG Xujun(Department of Respiratory Medicine,Jiujiang First People's Hospital,Jiangxi Province,Jiujiang332000,China)

机构地区：[1]江西省九江市第一人民医院呼吸内科,江西九江332000

出　　处：《中国当代医药》2022年第31期53-56,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202140253)。

摘　　要：目的探讨血清氨基末端B型脑钠肽前体(NT-proBNP)、前白蛋白(PA)、白细胞介素-32(IL-32)、白细胞介素-6(IL-6)在伴肺部感染急性心肌梗死(AMI)早期诊断和预后评估中的临床意义。方法选取2020年7月至12月九江市第一人民医院收治的63例伴肺部感染AMI患者作为观察组,选择同期于医院进行体检的32例健康体检者作为对照组。比较观察组和对照组的NT-proBNP、PA、IL-32及IL-6水平,分析各指标单独检测及联合检测对伴肺部感染AMI的诊断结果。根据是否发生不良心脏事件,将观察组患者分为预后良好组(46例)与预后不良组(17例),比较预后良好组与预后不良组患者的NT-proBNP、PA、IL-32及IL-6水平。结果观察组的NT-proBNP、IL-32、IL-6水平高于对照组,PA水平低于对照组,差异有统计学意义(P<0.05);NT-proBNP、IL-32、IL-6联合检测诊断伴肺部感染AMI的曲线下面积(AUC)为0.930(95%CI=0.886~0.963),敏感度为96.20%,特异度为81.21%,联合检测的敏感度高于单一指标检测;预后不良组患者的NT-proBNP、IL-32、IL-6水平高于预后良好组,PA水平低于预后良好组,差异有统计学意义(P<0.05)。结论NT-proBNP、PA、IL-32及IL-6联合诊断可提高伴肺部感染AMI的诊断价值,并可有效评估预后,指导治疗。Objective To investigate the clinical significance of serum N-terminal pro B-type brain natriuretic peptide(NT-proBNP),prealbumin(PA),interleukin-32(IL-32)and interleukin-6(IL-6)in the early diagnosis and prognosis of acute myocardial infarction(AMI)with pulmonary infection.Methods A total of 63 patients with AMI with pulmonary infection treated in Jiujiang First People's Hospital from July to December 2020 were selected as the observation group,and 32 healthy people who underwent physical examination in the same period were selected as the control group.The levels of NT-proBNP,PA,IL-32 and IL-6 in the observation group and the control group were compared,and the diagnostic results of each index alone and combined detection for AMI with pulmonary infection were analyzed.According to the occurrence of adverse cardiac events,the patients in the observation group were divided into good prognosis group(46 cases)and poor prognosis group(17 cases).The levels of NT-proBNP,PA,IL-32 and IL-6 in the good prognosis group and the poor prognosis group were compared.Results The levels of NT-proBNP,IL-32 and IL-6 in the observation group were higher than those in the control group,and the level of PA in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).The area under curve(AUC)of NT-proBNP,IL-32 and IL-6 combined detection in the diagnosis of AMI with pulmonary infection was 0.930(95%CI=0.886-0.963),the sensitivity was 96.20%,and the specificity was 81.21%.The sensitivity of combined detection was higher than that of single index detection.The levels of NT-proBNP,IL-32 and IL-6 in the poor prognosis group were higher than those in the good prognosis group,and the level of PA was lower than that in the good prognosis group,and the differences were statistically significant(P<0.05).Conclusion The combined diagnosis of NT-proBNP,PA,IL-32 and IL-6 can improve the diagnostic value of AMI with pulmonary infection,and can effectively evaluate the prognosis and gui

关 键 词：肺部感染 急性心肌梗死 氨基末端B型脑钠肽前体 前白蛋白 白细胞介素-32 白细胞介素-6 

分 类 号：R446.1[医药卫生—诊断学]