典型医用生物陶瓷HAP制备和性能研究  

Preparation of typical bio-ceramics HAP and its properties

作　　者：青薇 雷康丽 钟小峰 张婷[2] QING Wei;LEI Kangli;ZHONG Xiaofeng;ZHANG Ting(Department of Stomatology,the Third Affiliated Hospital of Chengdu Medical College/Pidu District People's Hospital,Chengdu 611730,China;Department of Biomedical Engineering,School of Big Health and Intelligent Engineering,Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院第三附属医院/成都市郫都区人民医院口腔科,四川成都611730 [2]成都医学院大健康与智能工程学院生物医学工程教研室,四川成都610500

出　　处：《中国医学物理学杂志》2022年第11期1417-1424,共8页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(U1833118);国家级大学生创新创业项目(S202013705004);省级大学生创新创业项目(202113705002);成都医学院—成都郫都区人民医院联合科研基金(2021LHPJ-03)。

摘　　要：羟基磷灰石(HAP)作为骨修复材料被广泛应用于临床口腔和骨科。本研究采用化学沉淀法中的氢氧化钙-磷酸体系进行HAP制备,同时使用Materials Studio 2017中的CASTEP模块对HAP的能带结构、态密度、力学性能、光学性质进行计算。结果发现温度越高,HAP的结晶度越好;pH值为10时所制得的HAP纯度最高;反应体系的陈化时间越长,得到的HAP规整度越高。本研究同时分析了杂质元素Zn对其力学性能、光学性质的作用机制,证明了掺杂元素Zn的HAP更适用于临床医学。研究结果为HAP复相陶瓷的制备与改性提供理论基础和参考依据。Hydroxyapatite(HAP)has been widely used in clinical stomatology and orthopedics as bone repair material.Herein the calcium hydroxide-phosphoric acid system in chemical precipitation is used for the preparation of HAP.Through the CASTEP module in Materials Studio 2017,the energy band structure,density of states,mechanical properties and optical properties of HAP are calculated.The results showed that the higher the temperature is,the better the HAP crystallinity is,and that the HAP prepared at pH value of 10 has the highest purity,and that the longer the aging time of the reaction system is,the higher the HAP regularity is.In addition,the mechanisms of action of the element Zn on the mechanical properties and optical properties of HAP are analyzed,and the results proved that the Zn-dopant HAP is more suitable for clinical medicine.The study provides theoretical basis as well as reference basis for the preparation and modification of HAP multiphase ceramics.

关 键 词：羟基磷灰石 化学沉淀法 密度泛函理论 电子结构 光学性质 

分 类 号：R318.08[医药卫生—生物医学工程] TB484.5[医药卫生—基础医学]