肿瘤光动力治疗中乏氧问题解决策略的研究进展  

Research Progress:Strategy to Solve Lack of Oxygen Existing in Tumor Photodynamic Therapy

作　　者：孙天真 李科锐 邱海霞 曾晶 顾瑛[1,2] 赵洪友 SUN Tianzhen;LI Kerui;QIU Haixia;ZENG Jing;GU Ying;ZHAO Hongyou(School of Medical Technology,Bejing Institute of Technology,Beijing 100081,China;Department of Laser Medicine,theFirst Medical Center of the PLAGeneral Hospital)

机构地区：[1]北京理工大学医学技术学院,北京市100081 [2]中国人民解放军总医院第一医学中心激光医学科

出　　处：《中国激光医学杂志》2022年第4期213-221,共9页Chinese Journal of Laser Medicine & Surgery

基　　金：北京理工大学青年教师学术启动计划(1870012222103);华中科技大学武汉光电国家研究中心开放基金课题(2020WNLOKF026);中国医学科学院医学与健康科技创新工程(2019-I2M-5-061)。

摘　　要：光动力疗法(photodynamic therapy,PDT)作为肿瘤治疗的一种新兴手段,已广泛应用于临床多种肿瘤的治疗。然而,PDT对氧气的依赖及肿瘤的乏氧环境严重限制了其治疗肿瘤的效果。近年来,解决PDT治疗肿瘤过程中的乏氧问题,提高其治疗效果已成为PDT领域的研究热点之一。本文从提高肿瘤组织的氧供给、肿瘤组织原位产氧、减少肿瘤耗氧、非氧气依赖的PDT等方面对肿瘤乏氧环境下增强PDT疗效的各种策略进行综合评述,为最终解决PDT治疗肿瘤过程中的乏氧问题提供参考。Photodynamic therapy(PDT),as a new method,has been widely used in treating various tumors.However,the oxygen consumption of PDT and the hypoxia environment of tumor tissues severely limit the efficacy of PDT.In recent years,how to solve the problem of oxygen deficiency that occurs commonly during PDT treatment has become one of the hottest research topics.In this paper,the strategies including improving oxygen supply,promoting oxygen production in tumors,reducing oxygen consumption of tumors and developing oxygen-independent PDT were reviewed with a view to providing references for solving the oxygen deficiency widely existing in tumor treatment with PDT.

关 键 词：光动力疗法 肿瘤 乏氧 解决策略 

分 类 号：R454.2[医药卫生—治疗学] R73[医药卫生—临床医学]