热休克蛋白在不明原因复发性流产中的研究进展  

Advances in the roles of heat shock proteins in unexplained recurrent spontaneous abortion

作　　者：王士萌 韩昕宇 亓丁 冯晓玲[2] Shi-meng Wang;Xin-yu Han;Ding Qi;Xiao-ling Feng(Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China;The First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中国现代医学杂志》2022年第22期69-74,共6页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:81973894)。

摘　　要：临床中常见不明原因复发性流产(URSA)。母胎界面免疫、子宫内膜蜕膜化、细胞自噬与凋亡、生殖细胞发育及男性精子因素、母体雌孕激素水平、同型半胱氨酸代谢等多种因素异常均与URSA有关。该文针对热休克蛋白在上述相关因素中的研究进行综述,以期为URSA病理机制和临床干预技术的进一步研究提供参考。Unexplained recurrent spontaneous abortion(URSA)is commonly seen in clinical practice.Multiple factors such as immune responses at the maternal-fetal interface,endometrial decidualization,autophagy and apoptosis,germ cell development,sperm abnormalities,maternal estrogen and progesterone levels and homocysteine metabolism are related to the occurrence of URSA.This review summarizes the studies on the roles of heat shock proteins in the aforementioned conditions,in order to provide references for the further investigation of the pathogenesis of and clinical intervention strategies for URSA.

关 键 词：复发性流产 热休克蛋白 妊娠 

分 类 号：R714.21[医药卫生—妇产科学]