黄连温胆汤对痰热瘀阻型原发性微血管心绞痛患者内皮功能的影响  

Effect of Huanglian Wendan Tang on Endothelial Function of Patients with Primary Microvascular Angina of Phlegm-Heat Stasis Obstruction Type

作　　者：黄琪[1] 隋向前[1] 王士生[1] 何武剑 王文婷 裴德安[1] 蒋凤春[1] 沈斌[1] HUANG Qi;SUI Xiangqian;WANG Shisheng;HE Wujian;WANG Wenting;PEI De'an;JIANG Fengchun;SHEN Bin

机构地区：[1]杭州市红十字会医院心血管内科,浙江杭州310003

出　　处：《新中医》2022年第18期29-34,共6页New Chinese Medicine

基　　金：浙江省中医药科技计划项目(2020ZA083);浙江省医药卫生科技计划项目(2019KY510,2020KY220)。

摘　　要：目的:观察痰热瘀阻型原发性微血管心绞痛(PMVA)患者在使用黄连温胆汤后血浆血管性假血友病因子(vWF)及同型半胱氨酸(Hcy)水平的变化,进而探讨痰热瘀阻型PMVA的发病机理。方法:选择经检查明确诊断为痰热瘀阻型PMVA的患者,共84例,随机分为常规治疗组和联合治疗组,常规治疗组根据病情予以常规药物治疗,联合治疗组在常规药物治疗基础上加用黄连温胆汤治疗,同时选择正常体检人群43例作为正常对照组,测定所有研究对象在入选时以及PMVA患者在治疗5 d后的vWF及Hcy水平。结果:PMVA组患者vWF水平较正常对照组显著升高,差异有统计学意义(P<0.01);PMVA组患者Hcy水平与正常对照组相当,差异无统计学意义(P>0.05)。联合治疗组和常规治疗组治疗后vWF水平均较治疗前显著下降,差异均有统计学意义(P<0.01);治疗后,联合治疗组vWF水平低于常规治疗组,差异有统计学意义(P<0.05);但联合治疗组vWF水平治疗前后差值11.819μg/L,常规治疗组vWF水平治疗前后差值7.407μg/L,2组治疗前后差值比较,差异无统计学意义(P>0.05)。PMVA组患者Hcy水平与正常对照组比较,差异无统计学意义(P>0.05)。结论:痰热瘀阻型PMVA患者vWF水平较正常体检人群显著升高,但Hcy水平与正常体检人群相当,PMVA患者在接受治疗后vWF水平均较治疗前水平有下降。联合黄连温胆汤治疗对vWF水平的影响,有可能优于单纯常规治疗。Objective:To observe the changes of the levels of plasma von willebrand factor(vWF) and homocysteine(Hcy) in patients with primary microvascular angina(PMVA) of phlegm-heat stasis obstruction type,and to explore the pathogenesis of PMVA with phlegm-heat stasis obstruction type. Methods:A total of 84 patients with PMVA of phlegm-heat stasis obstruction type were selected and randomly divided into the conventional treatment group and the combined treatment group. The conventional treatment group was treated with conventional medicine according to the condition,and the combined treatment group was additionally treated with Huanglian Wendan tang based on the treatment of conventional medicine. At the same time,43 healthy subjects were selected as the normal control group,and the vWF and Hcy levels of them when being involved in the study were determined,and the v WF and Hcy levels of PMVA patients after five days of treatment were also determined. Results: The level of vWF in the PMVA group was significantly increased when compared with that in the normal control group,the difference being significant(P<0.01),and the level of Hcy in the PMVA group was similar to that in the normal control group,there being no significant difference(P>0.05). The levels of vWF in the combined treatment group and the conventional treatment group were decreased significantly after treatment when compared with those before treatment, differences being significant(P<0.01);After treatment, the level of v WF in the combined treatment group was significantly decreased when compared with that in the normal control group,the difference being significant(P<0.05). The difference of vWF level before and after treatment in the combination treatment group,compared with that in the conventional treatment group,there being no significant difference between the two groups before and after treatment(P>0.05).There was no significant difference in the comparison of Hcy level between the PMVA group and the normal control group(P>0.05).Conclusion: The vWF l

关 键 词：原发性微血管心绞痛 痰热瘀阻型 黄连温胆汤 血管内皮功能 血管性假血友病因子 同型半胱氨酸 

分 类 号：R541.4[医药卫生—心血管疾病]