冠心宁片联合西药治疗冠心病合并轻度高血压病临床研究  

Clinical Study on Guanxinning Tablets Combined with Western Medicine for Coronary Heart Disease Complicated with Mild Hypertension

作　　者：田祖云 TIAN Zuyun

机构地区：[1]安吉县中医医院内一科,浙江安吉313300

出　　处：《新中医》2022年第18期35-39,共5页New Chinese Medicine

基　　金：浙江省医学会临床科研资金项目(2019ZYC-A31)。

摘　　要：目的:观察冠心宁片联合西药治疗冠心病合并轻度高血压病的临床疗效。方法:选取150例冠心病合并轻度高血压病患者,按随机数字表法分为对照组及观察组各75例。对照组采用常规西药治疗,观察组在对照组基础上加用冠心宁片治疗。比较2组临床疗效,比较2组治疗前后心绞痛发作频率、持续时间、血压、血管内皮功能指标[一氧化氮(NO)、血栓素B2(TXB2)、内皮素-1(ET-1)]、炎症因子[白细胞介素-6 (IL-6)、超敏C-反应蛋白(hs-CRP)、白细胞介素-10 (IL-10)]、血液流变学指标[红细胞比容(HCT)、全血高切黏度(BVH)、血浆黏度(PV)]的变化。结果:治疗后,观察组临床疗效总有效率为96.00%,对照组为86.67%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组心绞痛发作频率、持续时间较治疗前下降,差异均有统计学意义(P<0.05);治疗后,观察组心绞痛发作频率、持续时间均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组收缩压、舒张压水平均较治疗前下降,观察组2项水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组NO水平均较治疗前升高,TXB2、ET-1水平均较治疗前下降,差异均有统计学意义(P<0.05);治疗后,观察组NO水平高于对照组,TXB2、ET-1水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组IL-6、hs-CRP水平均较治疗前降低,IL-10水平均较治疗前升高,差异均有统计学意义(P<0.05);治疗后,观察组IL-6、hs-CRP水平均低于对照组,IL-10水平高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组BVH、PV、HCT指标值均较治疗前下降,观察组上述3项指标值均低于对照组,差异均有统计学意义(P<0.05)。治疗期间,2组均未出现严重药物不良反应病例。结论:冠心宁片联合西药治疗冠心病合并轻度高血压病疗效显著,可有效改善患者血管内皮功能及血液流变学,减轻机体炎症反应。Objective: To observe the clinical effect of Guanxinning tablets combined with western medicine for coronary heart disease complicated with mild hypertension. Methods:A total of 150 cases of patients with coronary heart disease complicated with mild hypertension were selected and divided into the control group and the observation group according to the random number table method,with 75 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with Guanxinning tablets based on the treatment of the control group. The clinical effects in the two groups were compared. Before and after treatment,the changes in frequency and duration of angina pectoris attack, blood pressure, vascular endothelial function indexes including nitric oxide(NO),thromboxane B2(TXB2) and endothelin-1(ET-1), inflammatory factors including interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP) and interleukin-10(IL-10),and hematocrit(HCT),whole blood high shear viscosity(BVH) and plasma viscosity(PV) in the two groups were compared. Results: After treatment,the total effective rate of clinical effect was 96.00% in the observation group and 86.67% in the control group, the difference being significant(P<0.05). After treatment, the frequency and duration of angina pectoris attack in the two groups were decreased when compared with those before treatment,differences being significant(P<0.05). After treatment,frequency and duration of angina pectoris attack in the observation group were lower than those in the control group,differences being significant(P<0.05).After treatment,the levels of systolic blood pressure and diastolic blood pressure in the two groups were decreased when compared with those before treatment,and the above two levels in the observation group were lower than those in the control group, differences being significant(P<0.05). After treatment, the levels of NO in the two groups were increased when compared with those before treatment,and the levels

关 键 词：冠心病 轻度高血压病 冠心宁片 血管内皮功能 血液流变学 

分 类 号：R541.4[医药卫生—心血管疾病] R544.1[医药卫生—内科学]