白芍总苷胶囊联合雷公藤多苷片治疗类风湿性关节炎临床研究  

Clinical Study on Total Glucosides of Paeony Capsules Combined with Tripterygium Wilfordii Glycosides Tablets for Rheumatoid Arthritis

作　　者：马丽丽 周攀 陈宁 潘林锋 MA Lili;ZHOU Pan;CHEN Ning;PAN Linfeng

机构地区：[1]舟山市普陀区人民医院风湿科,浙江舟山316100 [2]舟山市普陀区人民医院中医内科,浙江舟山316100 [3]浙江大学舟山医院普外科,浙江舟山316100

出　　处：《新中医》2022年第18期74-78,共5页New Chinese Medicine

摘　　要：目的:观察白芍总苷胶囊联合雷公藤多苷片治疗类风湿性关节炎(RA)的临床疗效。方法:选取76例RA患者,按随机数字表法分为对照组和研究组各38例。所有患者均给予甲氨蝶呤片、硫酸羟氯喹片等常规治疗,对照组加用雷公藤多苷片治疗,研究组在对照组基础上联合白芍总苷胶囊治疗。2组疗程均为8周。观察比较2组临床总有效率,以及治疗前后关节症状、健康评估问卷(HAQ)评分、抗环瓜氨酸肽(CCP)抗体阳性率、类风湿因子(RF)阳性率的变化。结果:研究组总有效率为94.7%,对照组为76.3%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组关节症状压痛指数、功能障碍指数、晨僵时间、肿胀指数、疼痛指数比较,差异无统计学意义(P>0.05);治疗后,2组上述各项指标均较治疗前显著降低(P<0.05),且研究组上述各项指标均低于对照组(P<0.05)。治疗前,2组HAQ评分比较,差异无统计学意义(P>0.05);治疗后,2组HAQ评分较治疗前显著降低(P<0.05),且研究组HAQ评分低于对照组(P<0.05)。治疗前,2组抗CCP抗体、RF阳性率比较,差异无统计学意义(P>0.05);治疗后,2组抗CCP抗体、RF阳性率均较治疗前降低(P<0.05),且研究组抗CCP抗体、RF阳性率均低于对照组(P<0.05)。结论:白芍总苷胶囊联合雷公藤多苷片治疗RA患者,可更好地改善其症状体征、缓解疼痛、提高有效率及生活质量,降低RF阳性率及抗CCP抗体阳性率。Objective: To observe the clinical effect of the therapy of total glucosides of paeony capsules combined with tripterygium wilfordii glycosides tablets on rheumatoid arthritis(RA). Methods: A total of 76 RA patients were randomly divided into the control group and the study group,with 38 in each group. All patients received methotrexate tablets, hydroxychloroquine sulfate tablets and other conventional treatment;the control group was additionally treated with tripterygium wilfordii glycosides tablets,and the study group was additionally treated with total glucosides of paeony capsules combined with tripterygium wilfordii glycosides tablets based on the treatment of the control group. Both groups were treated for eight weeks. The clinical effects in the two groups after treatment were observed,and the joint symptoms,the score of Health Assessment Questionnaire(HAQ),the positive rate of anti-cyclic citrulline peptide(CCP) antibody, and the positive rate of rheumatoid factor(RF) before and after treatment were observed and compared. Results:The total effective rate was 94.7% in the study group and 76.3% in the control group, the difference being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of joint symptoms, including tenderness,dysfunction,morning stiffness,swelling and pain between the two groups(P>0.05). After treatment,the above indexes in the two groups were significantly lower than those before treatment(P<0.05),and the above indexes in the study group were lower than those in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of the HAQ scores between the two groups(P>0.05). After treatment, the HAQ scores in both groups were significantly decreased when compared with those before treatment(P<0.05),and the HAQ score in the study group was lower than that in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of the positi

关 键 词：类风湿性关节炎 白芍总苷胶囊 雷公藤多苷片 健康评估问卷 抗环瓜氨酸肽抗体 

分 类 号：R593.22[医药卫生—内科学]