补肾活血膏治疗肾虚血瘀型早发性卵巢功能不全临床研究  

Clinical Study on Bushen Huoxue Paste for Premature Ovarian Insufficiency of Kidney Deficiency and Blood Stasis Type

作　　者：姜云 童桔英 JIANG Yun;TONG Juying

机构地区：[1]浙江中医药大学附属四省边际中医院(衢州市中医院),浙江衢州324000

出　　处：《新中医》2022年第18期92-96,共5页New Chinese Medicine

基　　金：衢州市科技局课题(2020025)。

摘　　要：目的:观察补肾活血膏治疗肾虚血瘀型早发性卵巢功能不全(POI)的临床疗效及其对患者性满意度评分的影响。方法:将POI患者分为4组各30例。西药组予芬吗通治疗,中药组予院内制剂补肾活血膏治疗,中西医联合组予芬吗通联合补肾活血膏治疗,拒绝任何治疗的30例POI患者为对照组。观察比较治疗前后所有患者血清促卵泡生成激素(FSH)、促黄体生成激素(LH)、抗苗勒管激素(AMH)水平、体质量指数(BMI)、中医证候积分,以及性满意度评分情况。结果:最终纳入统计,西药组27例,中药组28例,中西医联合组25例,对照组30例。西药组、中药组、中西医联合组3组总有效率及痊愈率比较,差异均有统计学意义(P<0.05),中西医联合组优于中药组及西药组。4组BMI治疗前后分别比较,差异均无统计学意义(P>0.05);4组间BMI比较,差异无统计学意义(P>0.05)。治疗后,中药组、中西医联合组2组中医证候积分均较治疗前降低(P<0.05),3组间中医证候积分比较,中西医联合组<中药组<西药组,差异均有统计学意义(P<0.05)。治疗后,西药组、中药组、中西医联合组3组性满意度评分均较治疗前提高,差异均有统计学意义(P<0.05);中西医联合组及中药组性满意度评分均优于西药组,差异均有统计学意义(P<0.05)。治疗后,中药组、西药组、中西医联合组3组FSH、LH均较治疗前降低,差异均有统计学意义(P<0.05)。治疗后,中西医联合组及中药组AMH较治疗前升高,差异均有统计学意义(P<0.05)。中西医联合组AMH均高于中药组、西药组、对照组,差异均有统计学意义(P<0.05)。结论:补肾活血膏能明显改善早发性卵巢功能不全患者性激素水平,减轻临床症状,并能提高性满意度。Objective: To observe the clinical effect of Bushen Huoxue paste for premature ovarian insufficiency(POI) of the kidney deficiency and blood stasis type and its effects on sexual satisfaction scores.Methods: The POI patients were divided into four groups, with 30 cases in each group. The western medicine group was treated with fenmotone;the Chinese medicine group was treated with the hospital prescription, namely Bushen Huoxue paste;the integrated Chinese and western medicine group was treated with fenmotone and Bushen Huoxue paste;30 cases of POI patients who refused any treatment were enrolled in the control group. The levels of serum follicle stimulating hormone(FSH), luteinizing hormone(LH) and anti mullerian hormone(AMH), body mass index(BMI), Chinese medicine syndrome scores and sexual satisfaction scores of all patients before and after treatment were observed and compared. Results:Finally,there were 27 cases in the western medicine group,28 cases in the Chinese medicine group, 25 cases in the integrated Chinese and western medicine group, and 30 cases in the control group. The comparison of the total effective rates and the cure rates among the western medicine group, the Chinese medicine group, and the integrated Chinese and western medicine group showed significance in differences(P<0.05), and the two rates in the integrated Chinese and western medicine group were better than those in the western medicine group and the Chinese medicine group. There was no significant difference being found in the comparison of BMI before and after treatment in the four groups(P>0.05);there was no significant difference being found in the comparison of BMI among the four groups(P>0.05). After treatment, Chinese medicine syndrome scores in the Chinese medicine group and the integrated Chinese and western medicine group were decreased when compared with those before treatment,differences being significant(P<0.05). The scores from low to high were the integrated Chinese and western medicine group,the Chinese medicine group,

关 键 词：早发性卵巢功能不全 性激素 抗苗勒管激素 促卵泡生成激素 促黄体生成激素 性满意度 

分 类 号：R711.75[医药卫生—妇产科学]