小儿咳喘灵口服液联合常规疗法治疗痰热壅肺证小儿毛细支气管炎临床研究  

Clinical Study of Xiao’er Kechuanling Oral Liquids Combined with Routine Therapy for Bronchiolitis in Children with Phlegm-Heat Obstructing Lung Syndrome

作　　者：戴兴龙 吴建飞 DAI Xinglong;WU Jianfei

机构地区：[1]杭州市第九人民医院儿科,浙江杭州311225 [2]杭州市第九人民医院中医科,浙江杭州311225

出　　处：《新中医》2022年第18期101-104,共4页New Chinese Medicine

摘　　要：目的:观察小儿咳喘灵口服液联合常规疗法治疗痰热壅肺证小儿毛细支气管炎的临床疗效。方法:选取毛细支气管炎患儿82例,按照随机数字表法分为对照组和治疗组各41例。对照组给予吸入用布地奈德混悬液+吸入用硫酸沙丁胺醇溶液治疗,治疗组在对照组的基础上给予小儿咳喘灵口服液治疗。比较2组临床疗效、临床症状消失时间,以及治疗前后肺功能[潮气量(TV)、达峰时间比(tPTEF/tE)、达峰容积比(VPTEF/VE)]、降钙素原(PCT)、超敏C-反应蛋白(hs-CRP)水平。结果:治疗组总有效率为95.12%,对照组为75.61%,2组比较,差异有统计学意义(P<0.05)。治疗组咳嗽、喘息、湿啰音、三凹征等症状消失时间均明显短于对照组,差异有统计学意义(P<0.05)。治疗前,2组TV、tPTEF/tE、VPTEF/VE水平比较,差异无统计学意义(P>0.05);治疗后,2组TV、tPTEF/tE、VPTEF/VE水平较治疗前明显增加(P<0.05),且治疗组上述各项指标均明显高于对照组(P<0.05)。治疗前,2组血清PCT、hs-CRP水平比较,差异无统计学意义(P>0.05);治疗后,2组PCT、hs-CRP水平均较治疗前明显降低(P<0.05),且治疗组上述指标均明显低于对照组(P<0.05)。结论:在常规治疗的基础上联合小儿咳喘灵口服液治疗痰热壅肺证小儿毛细支气管炎,可改善患儿症状体征和肺功能,抑制炎症反应,提高临床疗效。Objective:To observe the clinical effect of Xiao’er Kechuanling oral liquids combined with routine therapy for bronchiolitis in children with phlegm-heat obstructing the lung syndrome. Methods:A total of 82 cases of children with bronchiolitis were selected and divided into the control group and the treatment group according to the random number table method,with 41 cases in each group. The control group was treated with budesonide suspension and salbutamol sulfate solution for inhalation, and the treatment group was additionally treated with Xiao’er Kechuanling oral liquids based on the treatment of the control group. Clinical effects and the disappearance time of clinical symptoms were compared between the two groups. The lung function [tidal volume(TV),peak time ratio(tPTEF/tE),peak volume ratio(VPTEF/VE)], and levels of procalcitonin(PCT) and high-sensitivity C-reactive protein(hs-CRP) before and after treatment in the two groups were compared. Results: The total effective rate was 95.12% in the treatment group, and 75.61% in the control group, the difference being significant(P<0.05). The disappearance time of cough,panting,moist rale,three-concave sign and other symptoms in the treatment group was obviously shorter than that in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of TV,tPTEF/tE and VPTEF/VE between the two groups(P>0.05). After treatment,TV,tPTEF/tE and VPTEF/VE in the two groups were significantly increased when compared with those before treatment(P<0.05),and the above indexes in the treatment group were significantly higher than those in the control group(P<0.05).Before treatment, there was no significant difference being found in the comparison of the levels of PCT and hs-CRP in serum between the two groups(P>0.05). After treatment,levels of PCT and hs-CRP in serum in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the above two in

关 键 词：小儿毛细支气管炎 痰热壅肺证 小儿咳喘灵口服液 布地奈德混悬液 吸入用硫酸沙丁胺醇溶液 肺功能 

分 类 号：R562.21[医药卫生—呼吸系统]