聚乙二醇化重组人粒细胞刺激因子在造血干细胞移植后促进造血恢复的疗效分析  

Treatment outcome of pegylated recombinant human granulocyte colony stimulating factor to promote hematopoietic reconstitution after allogeneic hematopoietic stem cell transplantation(allo-HSCT)

作　　者：张晓瀚[1] 陈诗彧 汪鹏程[1] 蔡云[1] 杜新[1] ZHANG Xiaohan;CHEN Shiyu;WANG Pengcheng;CAI Yun;DU Xin(The Second People’s Hospital of Shenzhen,Shenzhen 518053,China)

机构地区：[1]深圳市第二人民医院,深圳518053

出　　处：《广州医药》2022年第6期56-60,共5页Guangzhou Medical Journal

摘　　要：目的 观察聚乙二醇化重组人粒细胞刺激因子(PEG-rhG-CSF)与重组人粒细胞刺激因子(rhG-CSF)在造血干细胞移植后促进造血恢复的疗效对比。方法 回顾分析2016年1月—2020年12月以来在深圳市第二人民医院血液科进行造血干细胞移植的恶性血液疾病患者共100例,随机分为2组,分别在造血干细胞回输后给与聚乙二醇化重组人粒细胞刺激因子与重组人粒细胞刺激因子。结果 PEG-rhG-CSF组与rhG-CSF组中性粒细胞植入时间分别为(18.7±3.4)天、(18.0±3.1)天,P=0.281,无统计学差异。粒细胞缺乏伴发热在PEG-rhG-CSF组与rhG-CSF组分别发生26例、29例,发生率分别为53.06%、56.86%,P=0.89,无差异。用药次数分别为2.6次(2~5次)、18.1次(11~31次),P<0.05,差异有统计学意义。不良反应主要为骨痛、肌肉疼痛。结论 PEG-rhG-CSF组与rhG-CSF组结果相似,PEG-rhG-CSF具有用药次数少的优势。Objective The efficacy of pegylated recombinant human granulocyte stimulating factor(PEG-rhG-CSF) and recombinant human granulocyte stimulating factor(rhG-CSF) in promoting hematopoiesis recovery after hematopoietic stem cell transplantation.Methods The data of 100 patients with malignant blood diseases who underwent hematopoietic stem cell transplantation in the Hematology Department of Shenzhen Second People’s Hospital from January 2016 to December 2020 were retrospectively analyzed.They were randomly assigned to two groups, which accepted PEG-rhG-CSF and rhG-CSF respectively after hematopoietic stem cell transfusion.Results The time of neutrophil implantation in PEG-rhG-CSF group and rhG-CSF group were(18.7±3.4) days and(18.0±3.1) days respectively, P=0.281,showing no statistical difference.There were 26 cases of neutropenia with fever in PEG-rhG-CSF group and 29 cases in rhG-CSF group, with incidence of 53.06% and 56.86%(P=0.89),showing no statistical difference.The times of medication were 2.6 times(2-5 times) and 18.1 times(11-31 times),P<0.05,with significant statistical difference.The main adverse reactions were bone pain and muscle pain.Conclusions The outcomes of PEG-rhG-CSF group and rhG-CSF group were similar, PEG-rhG-CSF had the advantage of fewer times of medication.

关 键 词：聚乙二醇化重组人粒细胞刺激因子 造血干细胞移植 重组人粒细胞刺激因子 造血恢复 

分 类 号：R457.7[医药卫生—治疗学]