重组人促红细胞生成素联合成分输血治疗慢性贫血的临床效果  

Clinical effect of recombinant human erythropoietin combined with component blood transfusion in the treatment of chronic anemia

作　　者：郑天亮 陈小翠 ZHENG Tianliang;CHEN Xiaocui(Blood Transfusion Department,Xi'an Aerospace General Hospital,Xi'an 710100;Blood Donation Service Branch,Ankang Central Blood Station,Ankang 725000,China)

机构地区：[1]西安航天总医院输血科,陕西西安710100 [2]安康市中心血站献血服务科,陕西安康725000

出　　处：《临床医学研究与实践》2022年第33期30-34,共5页Clinical Research and Practice

基　　金：陕西省重点研发计划项目(No.S2020-XA-YBSF-0885)。

摘　　要：目的探讨重组人促红细胞生成素联合成分输血治疗慢性贫血的临床效果。方法选取2019年4月至2021年4月本院收治的128例慢性贫血患者作为研究对象,采用随机数字表法将其分为对照组和研究组,各64例。对照组采用成分输血治疗,研究组在对照组的基础上配合重组人促红细胞生成素治疗。比较两组的临床疗效、血红蛋白(Hb)水平、红细胞(RBC)、红细胞比容(HCT),肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、γ-干扰素(IFN-γ)水平、输血情况及不良反应发生情况。结果研究组的治疗总有效率为95.31%,明显高于对照组的82.81%,差异具有统计学意义(P<0.05)。治疗前,两组的Hb水平及RBC、HCT比较,差异无统计学意义(P>0.05);治疗后,两组的Hb水平及RBC、HCT明显高于治疗前,差异具有统计学意义(P<0.05);治疗后,研究组的Hb水平及RBC、HCT明显高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的TNF-α、IL-6、IFN-γ水平比较,差异无统计学意义(P>0.05);治疗后,两组的TNF-α、IL-6、IFN-γ水平明显低于治疗前,差异具有统计学意义(P<0.05);治疗后,研究组的TNF-α、IL-6、IFN-γ水平明显低于对照组,差异具有统计学意义(P<0.05)。研究组的每次输血间隔时间明显长于对照组,平均输血量明显少于对照组,差异具有统计学意义(P<0.05)。研究组的不良反应总发生率为6.25%,明显低于对照组的18.75%,差异具有统计学意义(P<0.05)。结论重组人促红细胞生成素联合成分输血治疗慢性贫血的临床效果较好,可有效提高Hb水平及RBC、HCT,降低炎症因子水平,减少平均输血量,且不良反应较少,从而能够改善贫血状态,促进患者机体快速恢复,值得临床推广与应用。Objective To investigate clinical effect of recombinant human erythropoietin combined with component blood transfusion in the treatment of chronic anemia.Methods A total of 128 patients with chronic anemia admitted in our hospital from April 2019 to April 2021 were selected as the research objects and divided into control group and study group by random number table method,with 64 cases in each group.The control group was treated with component blood transfusion,and the study group was treated with recombinant human erythropoietin on the basis of the control group.The clinical efficacy,hemoglobin(Hb)level,red blood cell(RBC),hematokrit(HCT),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interferon-γ(IFN-γ)levels,blood transfusion and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 95.31%,which was significantly higher than 82.81% in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in Hb level and RBC,HCT between the two groups(P>0.05);after treatment,the Hb level,RBC and HCT in the two groups were significantly higher than those before treatment,and the differences were statistically significant(P<0.05);after treatment,the Hb level,RBC and HCT in the study group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of TNF-α,IL-6 and IFN-γ between the two groups(P>0.05);after treatment,the levels of TNF-α,IL-6 and IFN-γ in the two groups were significantly lower than those before treatment,and the differences were statistically significant(P<0.05);after treatment,the levels of TNF-α,IL-6 and IFN-γ in the study group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The interval time of each blood transfusion in the study group was signifi

关 键 词：重组人促红细胞生成素 成分输血 慢性贫血 红细胞 血红蛋白 红细胞比容 

分 类 号：R556[医药卫生—血液循环系统疾病]