氨茶碱注射液联合沙美特罗替卡松吸入粉雾剂对老年支气管哮喘患者通气状态及NGF、IL-25、ICAM-1水平的影响  

Effects of aminophylline injection combined with salmeterol xinafoate and fluticasone propionate powder for inhalation on ventilation status and NGF,IL-25,ICAM-1 levels in elderly patients with bronchial asthma

作　　者：高仑[1] 贺外信 GAO Lun;HE Waixin(Respiratory and Critical Care Medicine Department,the First Hospital of Yulin,Yulin 718000;Respiratory and Critical Care Medicine Department,Yan'an People's Hospital,Yan'an 716000,China)

机构地区：[1]榆林市第一医院呼吸与危重症医学科,陕西榆林718000 [2]延安市人民医院呼吸与危重症医学科,陕西延安716000

出　　处：《临床医学研究与实践》2022年第33期52-55,82,共5页Clinical Research and Practice

摘　　要：目的探讨氨茶碱注射液联合沙美特罗替卡松吸入粉雾剂对老年支气管哮喘患者通气状态及神经生长因子(NGF)、白细胞介素-25(IL-25)、细胞间黏附分子-1(ICAM-1)水平的影响。方法选择2018年6月至2021年2月收治的86例老年支气管哮喘患者为研究对象,采用随机数字表法将其分为对照组(43例,沙美特罗替卡松吸入粉雾剂+常规治疗)和观察组(43例,氨茶碱注射液+沙美特罗替卡松吸入粉雾剂+常规治疗)。比较两组的治疗效果、症状消失时间、炎性因子水平、血气指标、肺部通气状态、NGF及ICAM-1水平。结果观察组的治疗总有效率为93.02%,高于对照组的76.74%,差异具有统计学意义(P<0.05)。观察组的喘憋、咳嗽、哮鸣音、湿啰音消失时间均短于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、IL-25水平低于对照组,干扰素-γ(INF-γ)水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的动脉血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))、呼气峰流速(PEF)、第1秒用力呼气容积/用力肺活量(FEV1/FVC)均高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的NGF、ICAM-1水平低于对照组,差异具有统计学意义(P<0.05)。结论氨茶碱注射液联合沙美特罗替卡松吸入粉雾剂治疗老年支气管哮喘的效果显著,可快速减轻患者的临床症状,改善炎性因子水平与通气状态,调节NGF、ICAM-1水平,值得临床推广和应用。Objective To investigate the effects of aminophylline injection combined with salmeterol xinafoate and fluticasone propionate powder for inhalation on ventilation status and nerve growth factor(NGF),interleukin-25(IL-25),intercellular adhesion molecules-1(ICAM-1)levels in elderly patients with bronchial asthma.Methods A total of 86elderly patients with bronchial asthma admitted from June 2018 to February 2021 were selected as the research objects,and the patients were divided into control group(43 cases,salmeterol xinafoate and fluticasone propionate powder for inhalation+conventional treatment)and observation group(43 cases,aminophylline injection+salmeterol xinafoate and fluticasone propionate powder for inhalation+conventional treatment)by random number table method.The therapeutic effect,symptom disappearance time,inflammatory factors levels,blood gas indexes,pulmonary ventilation status,NGF and ICAM-1 levels were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.02%,which was higher than 76.74% in the control group,and the difference was statistically significant(P<0.05).The disappearance time of dyspnea,cough,wheezing and moist rale in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and IL-25 in the observation group were lower than those in the control group,the level of interferon-γ(INF-γ)was higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the arterial oxygen saturation(SaO_(2)),arterial partial pressure of oxygen(PaO_(2)),peak expiratory flow(PEF)and forced expiratory volume in one second/forced vital capacity(FEV1/FVC)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of NGF and ICAM-1 in the observation group were

关 键 词：支气管哮喘 氨茶碱注射液 沙美特罗替卡松吸入粉雾剂 通气状态 神经生长因子 白细胞介素-25 细胞间黏附分子-1 

分 类 号：R562.2[医药卫生—呼吸系统]