溴敌隆中毒致消化道和腹腔出血后继发麻痹性肠梗阻1例  

A case of bromadiolone poisoning leading to digestive tract,abdominal hemorrhage and secondary paralytic ileus

作　　者：陈宏凡 张志坚[1,2] 游承劲 陈丽 Chen Hongfan;Zhang Zhijian;You Chengjin;Chen Li(Emergency Department of Banan District People's Hospital of Chongqing,Chongqing 401320,China;Critical Care Medicine of Banan District People's Hospital of Chongqing,Chongqing 401320,China)

机构地区：[1]重庆市巴南区人民医院急诊科,重庆401320 [2]重庆市巴南区人民医院重症医学科,重庆401320

出　　处：《中华劳动卫生职业病杂志》2022年第9期707-709,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：重庆市科卫联合中医药技术创新与发展项目(2020ZY023881)。

摘　　要：溴敌隆是一种长效香豆素类抗凝类杀鼠剂,俗称"超级华法林",其作用机制主要是抑制维生素K1环氧化物还原酶,影响凝血因子Ⅱ、Ⅶ、Ⅸ和Ⅹ的合成,致使机体凝血机能障碍,导致全身多脏器出血。本文报道一例溴敌隆中毒后导致消化道、腹腔出血,同时继发麻痹性肠梗阻的患者,给予输注血制品、补充维生素K1等治疗后,病情好转出院。提示临床医生在救治其他溴敌隆中毒时,要注意少见并发症,以免漏诊。Bromadiolone,commonly known as super warfarin,is a long-acting coumarin dicoumarin rodenticide.The mechanism of bromadiolone is mainly to inhibit vitamin K1 epoxide reductase and affect the synthesis of coagulation factorsⅡ,Ⅶ,ⅨandⅩ,which causes blood coagulation dysfunction and systemic multiple organ hemorrhage.Here,we report of a case of bromadiolone poisoning patient who had digestive tract,abdominal hemorrhage,as well as secondary paralytic ileus.After blood product transfusion and vitamin K1 supplementation,the patient was discharged after the physical condition was improved.It's suggestied that clinicians should pay attention to rare complications to prevent missed diagnosis when treating other bromadiolone poisoning.

关 键 词：中毒 溴敌隆 消化道出血 腹腔出血 麻痹性肠梗阻 影像学表现 

分 类 号：R595.4[医药卫生—内科学]