特发性肺纤维化相关的肺癌发病机制的研究进展  

Research Progress on the Pathogenesis of Lung Cancer Associated with Idiopathic Pulmonary Fibrosis

作　　者：卢蔷薇 韩闪 刘晓秋[1] Qiangwei LU;Shan HAN;Xiaoqiu LIU(Department of Respiratory and Critical Care Medicine,Second Hospital of Jilin University,Changchun 130000,China)

机构地区：[1]吉林大学第二医院呼吸与危重症医学科,长春130000

出　　处：《中国肺癌杂志》2022年第11期811-818,共8页Chinese Journal of Lung Cancer

基　　金：吉林省科技厅自然科学基金项目基金(No.20160101089JC);吉林省卫生计生科研计划课题(No.20152020)资助。

摘　　要：特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种原因不明的最常见的间质性肺疾病(interstitial lung disease,ILD),以最终导致肺间质纤维化为特征,确诊后的中位生存期为2年-4年。近年来,IPF相关的肺癌(lung cancer associated with IPF,IPF-LC)的发病率越来越高,且预后较单纯的IPF差。研究发现,IPF可能与肺癌的发生发展密切相关。尽管IPF-LC的发生机制尚不清楚,但目前的研究表示这两种疾病在分子及细胞水平的致病过程存在相似之处。目前肺纤维化相关的肺癌的细胞分子机制的研究已经成为研究者的关注焦点。本文通过回顾相关文献,以IPF-LC的细胞和分子机制及治疗最新现状为重点进行综述,希望能够提高临床医生对IPF-LC的认识。Idiopathic pulmonary fibrosis(IPF)is the most common interstitial lung disease(ILD)of unknown causes,which is characterized by pulmonary fibrosis.The median survival period after diagnosis is about 2-4 years.In recent years,the incidence rate of lung cancer associated with IPF(IPF-LC)is increasing,and the prognosis is worse than that of IPF alone.Pulmonary fibrosis may be closely associated with the occurrence and development of lung cancer.Although the pathogenesis of IPF-LC is still unclear,the current research shows that there are similarities between the pathogenesis of these two diseases at molecular and cellular levels.At present,the research on the cellular and molecular mechanism of lung cancer related to pulmonary fibrosis has become the focus of researchers’attention.This article reviews the related literature,focusing on the latest status of the cellular and molecular mechanisms and treatment of IPF-LC,hoping to help clinicians understand IPF-LC.

关 键 词：特发性肺纤维化 肺肿瘤 细胞 分子 发病机制 

分 类 号：R563[医药卫生—呼吸系统] R734.2[医药卫生—内科学]