谷胱甘肽维生素C片的安全性评价  

Safety evaluation of glutathione with vitamin C tablets

作　　者：凌敏[1] 施伟庆[1] 张薇 梁婕[1] LING Min;SHI Weiqing;ZHANG Wei;LIANG Jie(Institute of Toxicology and Risk Assessment,Jiangsu Center for Disease Control and Prevention,Nanjing 210009,Jiangsu,China)

机构地区：[1]江苏省疾病预防控制中心毒理与风险评估研究所,江苏南京210009

出　　处：《癌变．畸变．突变》2022年第6期467-470,475,共5页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的:对谷胱甘肽维生素C(Vit.C)片进行大鼠30天喂养试验的安全性评价。方法:将谷胱甘肽Vit.C片以417、834、1667 mg/kg(相当于人体推荐剂量的25、50、100倍)的剂量连续饲喂大鼠30天。期间每天观察动物的一般表现,每周记录大鼠体质量、进食量;30天后进行大鼠血清生化和血液学指标检测,取肝、脾、肾、胃、睾丸等主要脏器称量后计算脏器系数,并且进行组织病理学检查。结果:试验期间大鼠一般情况良好,与对照组比较,试验组大鼠体质量无明显变化(P>0.05);血液学及血生化指标结果均在正常值范围(P>0.05);各脏器系数变化不明显,差异均无统计学意义(P>0.05);高剂量组各器官未检出明显的病理学改变。结论:在本试验条件下,谷胱甘肽Vit.C片对大鼠未造成明显的不良影响。OBJECTIVE:Safety of glutathione with vitamin C tablets was preliminarily evaluated by feeding rats with the tablets for 30 days.METHODS:Glutathione with vitamin C tablets were given 417,834,1667 mg/kg(equivalent to 25,50,100 times of the recommended dose in human)to rats for 30 days.General activities of rats were observed every day,and their body weights and food intakes were recorded every week.After 30 days,serum biochemical and hematological indexes were detected.The main organs such as liver,kidney,spleen,stomach,testis were weighed and organ coefficients were calculated,and histopatho logical examination was performed.RESULTS:During the test,the rats were generally in good condition.Compared with the control group,the body weights of rats in the test group were not significantly abnormal(P>0.05).Results of hematology and blood biochemical indexes were within the normal range(P>0.05).There was no significant difference in organ coefficients(P>0.05)and no obvious pathological changes were found in the organs of the high-dose group.CONCLUSION:Under the experimental conditions,glutathione with vitamin C tablets had no harmful effects in rats.

关 键 词：谷胱甘肽 维生素C 30天喂养试验 安全性评价 

分 类 号：S859.83[农业科学—临床兽医学]