非编码RNA在结核病中的研究进展  

Research progress of non-coding RNA tuberculosis

作　　者：朱银银 张洪英[1,2] Zhu Yinyin;Zhang Hongying(Microbiological Laboratory,Nanjing Center for Disease Control and Prevention Affiliated to Nanjing Medical University,Nanjing 210003,China;School of Public Health Nangjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学附属南京疾病预防控制中心微生物实验室,南京210003 [2]南京医科大学公共卫生学院,南京211166

出　　处：《中国防痨杂志》2022年第12期1358-1362,共5页Chinese Journal of Antituberculosis

基　　金：中国疾病预防控制中心公共卫生领域卫生健康标准评估项目(2021-05-20);南京市卫生健康委员会医学重点科技发展项目(zkx2019048)。

摘　　要：结核病是结核分枝杆菌引起的慢性传染病,是世界上最严重的传染病之一。尽管结核病的检测技术和治疗方法已取得重大进展,但仍缺少早期筛查和针对性治疗的解决方案。非编码RNA(non-coding RNA,ncRNA)广泛参与包括结核分枝杆菌感染在内的多种生物学过程,并发挥着重要作用。针对机体与结核分枝杆菌的相互作用,笔者对结核分枝杆菌感染人体过程中宿主ncRNA的研究进展及调控机制进行综述,以为结核病的诊断和新抗结核治疗方法的开发带来潜在的临床前景。Tuberculosis,a chronic infectious disease caused by Mycobacterium tuberculosis,is one of the most serious infectious disease in the world.Despite significant advances in detection techniques and therapeutic approaches for tuberculosis,there is still lack of early screening methods and targeted treatment.Non-coding RNA(ncRNA)widely participate in various biological processes,including Mycobacterium tuberculosis infection,and play critical roles.In view of the interaction of the host with Mycobacterium tuberculosis,the author reviewed research progress and regulation mechanism of host ncRNA in the tuberculosis infection process in human and regulation mechanism,to bring potential clinical prospects for tuberculosis diagnosis and the development of new anti-tuberculosis therapies.

关 键 词：分枝杆菌 结核 RNA探针 生物学标记 综述 

分 类 号：R52[医药卫生—内科学] R446.61[医药卫生—临床医学] R-1