临床标本中结核分枝杆菌抗原蛋白鉴定的研究进展  

Progress in the identification of Mycobacterium tuberculosis antigenic proteins in clinical specimens

作　　者：盛钢 褚洪迁 刘丁一 孙照刚[1] Sheng Gang;Chu Hongqian;Liu Dingyi;Sun Zhaogang(Translational Medicine Center,Beijing Chest Hospital,Captial Medical University/Beijing Key Laboratory in Drug Resistant Tuberculosis Research,Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院转化医学研究室/北京市结核病胸部肿瘤研究所耐药结核病研究北京市重点实验室,北京101149

出　　处：《中国防痨杂志》2022年第12期1363-1368,共6页Chinese Journal of Antituberculosis

基　　金：北京市卫生健康委员会-首都卫生发展科研专项项目(2022-1G-2161)。

摘　　要：结核病是由结核分枝杆菌感染导致的严重的呼吸系统传染病,其传播隐匿,防控难度大。目前的结核病快速发现技术存在一定缺陷,亟需新的诊断技术。抗原检测技术具有适用广泛、操作简便、快速精确的优点,但尚未发现具有良好的稳定检测效果的靶标。另外,即使是针对同一抗原靶标,不同研究的检测效能差异也较大。因此,笔者对不同鉴定方法和实验研究证实的各种临床标本中存在的抗原蛋白的检测状况进行综述,以重新思考结核分枝杆菌抗原在临床标本中实际存在的状态和含量,以及改进抗原发现和鉴定的方法,为结核病抗原诊断技术的发展提供理论参考。Tuberculosis(TB)is a serious respiratory disease caused by Mycobacterium tuberculosis(MTB)infection.The spread of TB is hidden,and it is difficult to prevent and control.The current rapid detection technology of TB has certain shortcomings and new diagnostic technology is urgently needed.Antigen detection technology of TB is widely applicable,simple,rapid and accurate.However,no target with good and stable detection effect has been found,and even for the same antigen target,the detection efficiency of different studies varies greatly.Therefore,we reviewed the detection status of antigenic proteins in various clinical specimens confirmed by different identification methods and experimental studies,to reconsider the status and content of MTB antigens in clinical specimens,and improve the method of antigen discovery and identification,so as to provide the theoretical reference for the development of diagnostic technology for tuberculosis antigens.

关 键 词：分枝杆菌 结核 抗原 免疫学 生物学鉴定法 综述文献(主题) 

分 类 号：R378.91[医药卫生—病原生物学] R392[医药卫生—基础医学]