乙酰谷酰胺注射液辅助治疗酒精中毒昏迷患者的效果  

Effects of Acetylglutamide injection in adjuvant treatment of alcoholic coma

作　　者：谢东莞 XIE Dongguan(Department of Emergency of Putian Medical District of Joint Logistics Support Force No.900 Hospital,Putian 351100 Fujian,China)

机构地区：[1]联勤保障部队第九〇〇医院莆田医疗区急诊科,福建莆田351100

出　　处：《中国民康医学》2022年第20期45-48,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察乙酰谷酰胺注射液辅助治疗酒精中毒昏迷患者的效果。方法:选取2019年2月至2021年9月该院收治的87例酒精中毒昏迷患者进行前瞻性研究,按照随机数字表法分为对照组43例和观察组44例。对照组给予盐酸纳洛酮治疗,观察组在对照组基础上给予乙酰谷酰胺注射液治疗,比较两组治疗效果、治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和γ-谷氨酰转肽酶(γ-GT)]水平、神经功能指标[脑脊液β-内啡肽(β-EP)、血清超氧化物歧化酶(SOD)、丙二醛(MDA)]水平和酒后不适症状发生率。结果:观察组治疗总有效率为95.45%(42/44),高于对照组的79.07%(34/43),差异有统计学意义(P<0.05);治疗后,两组ALT、AST、γ-GT、β-EP和MDA水平均低于治疗前,且观察组低于对照组,两组SOD水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组酒后头晕头痛、恶心呕吐、乏力和胸闷等酒后不适症状发生率均低于对照组,差异有统计学意义(P<0.05)。结论:乙酰谷酰胺注射液辅助治疗酒精中毒昏迷患者可提高治疗总有效率和肝功能指标水平,改善神经功能指标水平,降低酒后不适症状发生率,效果优于单纯盐酸纳洛酮治疗。Objective:To observe effects of Acetylglutamide injection in adjuvant treatment of alcoholic coma.Methods:A prospective study was conducted on 87 patients with alcoholic coma admitted to the hospital from February 2019 to September 2021.They were divided into control group(43 cases)and observation group(44 cases)according to the random number table method.The control group was treated with Naloxone hydrochloride,while the observation group was treated with Acetylglutamide injection on the basis of that of the control group.The therapeutic effect,the levels of liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST)andγ-glutamyl transpeptidase(γ-GT)],the nerve function index[cerebrospinal fluidβ-endorphin(β-EP),serum superoxide dismutase(SOD),malondialdehyde(MDA)]levels,and the incidence of the uncomfortable symptoms after drinking were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.45%(42/44),which was higher than 79.07%(34/43)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of ALT,AST,γ-GT,β-EP and MDA in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the SOD levels in the two groups were higher than those before the treatment,and that of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).The incidence of the uncomfortable symptoms including dizziness,headache,nausea and vomiting,fatigue and chest tightness in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Acetylglutamide injection in the adjuvant treatment of the patients with alcoholic coma can improve the total effective rate of treatment and the liver function index levels,improve the levels of nerve function index,and reduce the incidence of the uncomfortable sy

关 键 词：酒精中毒昏迷 乙酰谷酰胺注射液 盐酸纳洛酮 肝功能 神经功能 

分 类 号：R459.7[医药卫生—急诊医学]