复方霜桑叶合剂联合磷酸哌喹治疗尘肺病患者的效果  

Effects of compound frost mulberry leaf mixture combined with Piperaquine phosphate in treatment of pneumoconiosis

作　　者：郭中建 GUO Zhongjian(Dengfeng Songzheng Hospital of Traditional Chinese Medicine,Dengfeng 452470 Henan,China)

机构地区：[1]登封嵩正中医院,河南登封452470

出　　处：《中国民康医学》2022年第20期111-114,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察复方霜桑叶合剂联合磷酸哌喹治疗尘肺病患者的效果。方法:选取2019年1月至2020年12月该院收治的100例尘肺病患者进行前瞻性研究,采用随机数字表法分为对照组和观察组各50例。对照组给予高压氧联合磷酸哌喹治疗,观察组采用复方霜桑叶合剂联合磷酸哌喹治疗。比较两组治疗前后肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC]水平、血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、血氧饱和度(SpO_(2))]、T细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、生化指标(血清铜蓝蛋白、溶酶菌、黏蛋白、尿羟脯氨酸)水平,以及生命质量[圣乔治呼吸问卷(SGRQ)]评分和不良反应发生率。结果:治疗后,两组FEV_(1)、FVC、FEV_(1)/FVC、PaO_(2)、SpO_(2)、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组PaCO_(2)、CD8^(+)、血清铜蓝蛋白、溶酶菌、黏蛋白、尿羟脯氨酸水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗3、6个月后,两组SGRQ评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为4.00%,低于对照组的20.00%,差异有统计学意义(P<0.05)。结论:复方霜桑叶合剂联合磷酸哌喹治疗尘肺病患者可提高肺功能指标水平,改善血气指标和T细胞亚群指标水平,降低生化指标水平、SGRQ评分和不良反应发生率,优于高压氧联合磷酸哌喹治疗效果。Objective:To observe effects of compound frost mulberry leaf mixture combined with Piperaquine phosphate in treatment of pneumoconiosis.Methods:A prospective study was conducted on 100 pneumoconiosis patients admitted to the hospital from January 2019 to December 2020.They were divided into control group and observation group by using the random number table method,50 cases in each group.The control group was treated with hyperbaric oxygen combined with Piperaquine phosphate,while the observation group was treated with compound frost mulberry leaf mixture combined with Piperaquine phosphate.The levels of lung function indexes[forced expiratory volume in the first second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC],the blood gas indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),blood oxygen saturation(SpO_(2))]levels,the T cell subset indexes(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))levels,the biochemical indexes(serum ceruloplasmin,lysozyme,mucin,urinary hydroxyproline)levels,the quality of life[St.George’s respiratory questionnaire(SGRQ)]score,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of FEV_(1),FVC,FEV_(1)/FVC,PaO_(2),SpO_(2),CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PaCO_(2),CD8^(+),serum ceruloplasmin,lysozyme,mucin and urinary hydroxyproline in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).3 and 6 months after the treatment,the SGRQ scores of the two groups were lower than those before the treatment,those in the observation group were lower those in than the control group,and the diffe

关 键 词：复方霜桑叶合剂 尘肺病 T细胞亚群 不良反应 血气 肺功能 

分 类 号：R135.2[医药卫生—劳动卫生]