艾司洛尔与胺碘酮治疗急性心力衰竭合并快速心室率房颤患者的效果比较  

Comparison of effects of Esmolol and Amiodarone in treatment of patients with acute heart failure complicated with atrial fibrillation of fast ventricular rate

作　　者：陈晶辉 CHEN Jinghui(Liaoyang County Thrombosis Hospital,Liaoyang 111000 Liaoning,China)

机构地区：[1]辽阳县血栓病医院,辽宁辽阳111000

出　　处：《中国民康医学》2022年第20期133-136,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较艾司洛尔与胺碘酮治疗急性心力衰竭合并快速心室率房颤患者的效果。方法:选取2019年2月至2021年3月该院收治的100例急性心力衰竭合并快速心室率房颤患者进行前瞻性研究,以抽签法分为对照组(n=50)和观察组(n=50)。对照组采用胺碘酮治疗,观察组采用艾司洛尔治疗,比较两组治疗效果、治疗前后心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)、每搏输出量(SV)]水平、血清学指标[血管紧张素-Ⅱ(Ang-Ⅱ)、去甲肾上腺素(NE)、B型脑钠肽(BNP)]水平、心室率和不良反应发生率。结果:观察组治疗总有效率为98.00%(49/50),高于对照组的84.00%(42/50),差异有统计学意义(P<0.05);治疗后,观察组LVEDD、LVESD水平均低于对照组,LVEF、SV水平均高于对照组,差异有统计学意义(P<0.05);治疗后,两组Ang-Ⅱ、NE、BNP水平和心室率均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为4.00%(2/50),低于对照组的18.00%(9/50),差异有统计学意义(P<0.05)。结论:艾司洛尔治疗急性心力衰竭合并快速心室率房颤患者可提高治疗总有效率,改善心功能指标水平,降低血清学指标水平、心室率和不良反应发生率,效果优于胺碘酮治疗。Objective: To compare effects of Esmolol and Amiodarone in treatment of patients with acute heart failure complicated with atrial fibrillation of fast ventricular rate. Methods: A prospective study was conducted on 100 patients with acute heart failure and atrial fibrillation of fast ventricular rate admitted to the hospital from February 2019 to March 2021. They were divided into control group(n=50) and observation group(n=50) by the lottery method. The control group was treated with Amiodarone, while the observation group was treated with Esmolol. The therapeutic effect, the levels of cardiac function indexes [left ventricular end-diastolic diameter(LVEDD), left ventricular end-systolic diameter(LVESD), left ventricular ejection fraction(LVEF), stroke volume(SV)], the serological index levels [angiotensin-Ⅱ(Ang-Ⅱ), norepinephrine(NE), B-type brain natriuretic peptide(BNP)], the ventricular rate, and the incidence of adverse reactions during treatment were compared between the two groups.Results: The total effective rate of treatment in the observation group was 98.00%(49/50), which was higher than 84.00%(42/50) in the control group, and the difference was statistically significant(P<0.05). After the treatment, the levels of LVEDD and LVESD in the observation group were lower than those in the control group, the levels of LVEF and SV were higher than those in the control group, and the differences were statistically significant(P<0.05). After the treatment, the levels of Ang-Ⅱ, NE, BNP and ventricular rate in the two groups were lower than those before the treatment, those in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05).Further, the incidence of adverse reactions of the observation group was 4.00%(2/50), which was lower than 18.00 %(9/50) in the control group, and the difference was statistically significant(P<0.05). Conclusions: Esmolol in the treatment of the patients with acute heart failure complicated with atrial fibrillat

关 键 词：胺碘酮 艾司洛尔 急性心力衰竭 快速心室率房颤 心功能 心室率 

分 类 号：R541.7[医药卫生—心血管疾病]