针灸治疗阿尔茨海默病机制的研究进展  

Research Progress on Mechanism of Acupuncture Treatment of Alzheimer's Disease

作　　者：陈振兴 王鹤淞 张沥丹 陈新华[1] Chen Zhenxing;Wang Hesong;Zhang Lidan;Chen Xinhua(Changchun University of Traditional Chinese Medicine,Changchun 130117)

机构地区：[1]长春中医药大学,长春130117

出　　处：《国际老年医学杂志》2022年第6期738-741,共4页International Journal of Geriatrics

基　　金：吉林省科学技术厅项目(20190201147JC)。

摘　　要：阿尔茨海默病(AD)是一种与衰老密切相关,以认知功能及行为异常为主要表现的神经系统退行性疾病。针灸作为AD治疗的重要手段之一,可能通过调控AD相关蛋白的水平、清除自由基与调节线粒体能量代谢、调节哺乳动物雷帕霉素靶蛋白(mTOR)信号相关通路、抑制胶质细胞的过度活化、调节糖脂代谢异常、抑制细胞凋亡等途径治疗AD。本文对上述机制作一综述,为临床针灸治疗AD提供参考。Alzheimer's disease(AD)is a neurodegenerative disease which closely related to aging and characterized by cognitive and behavioral abnormalities.Acupuncture as one of the important therapies for AD may regulate the level of AD-related proteins,scavenge free radicals,modolate mitochondrial energy metabolism,regulate the signaling pathway of mammalian rapamycin target protein(mTOR),inhibit the excessive activation of glial cells,regulate abnormal glycolipid metabolism and inhibit apoptosis.The above mechanisms are reviewed in order to provide references for the acupuncture treatment on AD.

关 键 词：阿尔茨海默病 针灸 机制研究 

分 类 号：R246.6[医药卫生—针灸推拿学]