N-杂环卡宾金属配合物抗肿瘤和抗菌活性的研究进展  

Advances in antitumor and antibacterial activities of N-heterocyclic carbine-metal complexes

作　　者：卢倩倩 刘英[1,2] 严密 刘彬彬 蔡轶 王君[1,3] 邹黎黎[1,2] LU Qianqian;LIU Ying;YAN Mi;LIU Binbin;CAI Yi;WANG Jun;ZOU Lili(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,China Three Gorges University,Hubei Province,Yichang 443000,China;the Institution of Infection and Inflammation,Medical College,China Three Gorges University,Hubei Province,Yichang 443000,China;Department of Science and Technology,the People’s Hospital of China Three Gorges University,Hubei Province,Yichang 443000,China)

机构地区：[1]三峡大学肿瘤微环境与免疫治疗湖北省重点实验室,湖北宜昌443000 [2]三峡大学感染与炎症损伤研究所,湖北宜昌443000 [3]三峡大学第一人民医院科技科,湖北宜昌443000

出　　处：《中国医药导报》2022年第32期31-34,46,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(81903105);湖北省宜昌市医疗卫生科研项目(A19-301-50)。

摘　　要：自Arduengo在1991年首次成功分离到稳定的游离N-杂环卡宾化合物(NHC)以来,其作为过渡金属配合物新型配体的研究得到迅猛发展。NHC金属配合物除了在催化、合成和材料等方面得到广泛应用外,在治疗方面的应用也值得特别关注。近年来研究发现,NHC-金属配合物在抗肿瘤和抗微生物方面展现出良好的生物活性,具有巨大应用前景。基于此,本文就NHC-金(Au)、NHC-银(Ag)、NHC-钯(Pd)、NHC-铂的抗恶性肿瘤增殖活性及NHC-Au、NHC-Ag、NHC-Pd的抗微生物活性进行简要综述。Since Arduengo’s first successful isolation of stable free N-heterocyclic carbinol compounds(NHC)in 1991,its research as a novel ligand for transition metal complexes has developed rapidly.NHC metal complexes deserve special attention for their therapeutic applications in addition to their wide range of applications in catalysis,synthesis and materials.Recent studies have revealed that NHC-metal complexes exhibit good biological activities in anti-tumor and anti-microbial aspects and have great application prospects.Based on this,a brief review of the anti-malignant proliferative activity of NHC-gold(Au),NHC-silver(Ag),NHC-palladium(Pd),and NHC-platinum and the anti-microbial activity of NHC-Au,NHC-Ag,and NHC-Pd is presented.

关 键 词：N-杂环卡宾化合物 N-杂环卡宾金属 抗肿瘤 抗菌 最小抑菌浓度 

分 类 号：O621.258[理学—有机化学]