啮齿类动物烟碱依赖相关的行为学评价方法  

Nicotine addiction models and evaluation of animal behavior

作　　者：李凯欣 陈欢[1] 刘方邻 刘勇[3] 侯宏卫[1] 胡清源[1,2,3] LI Kaixin;CHEN Huan;LIU Fanglin;LIU Yong;HOU Hongwei;HU Qingyuan(China Tobacco Quality Supervision and Test Center,Key Laboratory of Tobacco Biological Effects,Joint Laboratory of Translational Neurobiology,Zhengzhou 450001,China.;University of Science and Technology of China,Hefei 230026;Hefei Institute of Physical Sciences,Chinese Academy of Sciences,Hefei 230031)

机构地区：[1]国家烟草质量监督检验中心,烟草生物学效应重点实验室,转化神经生物学联合实验室,郑州450001 [2]中国科学技术大学,合肥230026 [3]中国科学院合肥物质科学研究院,合肥230031

出　　处：《中国实验动物学报》2022年第6期830-838,共9页Acta Laboratorium Animalis Scientia Sinica

基　　金：省部级重点科技项目(110202101018(XX-04),110202102014)。

摘　　要：吸烟人口众多对社会的影响广泛,其中烟碱是烟气中最为关注的药理学成分之一。长期摄入烟碱会导致烟碱依赖行为,烟碱依赖会影响依赖者的大脑高级功能,可能涉及焦虑、学习记忆障碍以及决策能力异常等。为方便研究烟碱依赖的分子机制,目前普遍通过构建啮齿类烟碱依赖动物模型,以更好的研究其各项生理变化。本综述对已有的动物行为学评价实验在烟碱依赖动物模型中的应用进行总结及评价,以期为研究者构建啮齿类动物烟碱依赖评价模型提供可靠的参考依据。The large number of smokers has had a broad effect on society.Nicotine is one of the most widely concerning components of cigarette smoke.Long-term intake of nicotine can lead to nicotine dependence that affects higher brain functions,which may involve anxiety,learning and memory impairments,and abnormal decision-making.To facilitate analyzing the molecular mechanisms of nicotine dependence,it is common to establish rodent nicotinoid dependence models to better understand the physiological changes.This review summarizes and evaluates studies of the behavior in nicotine-dependent animal models to provide a reliable reference for researchers to establish rodent nicotinedependent models for evaluation.

关 键 词：烟碱依赖 成瘾动物模型 动物行为学 啮齿类动物 评价方法 

分 类 号：Q95-33[生物学—动物学]