气相色谱质谱法测定化妆品中薄荷醇和薄荷醇乳酸酯  

Determination of menthol and menthyl lactate in cosmetics by GC-MS

作　　者：熊智 施佳佳 何泉泉 Zhi Xiong;Jiajia Shi;Quanquan He(Amorepacific(Shanghai)R&I Center Co.,Ltd.,Shanghai 201801,China)

机构地区：[1]爱茉莉太平洋(上海)研发有限公司,上海201801

出　　处：《日用化学工业（中英文）》2022年第11期1254-1258,共5页China Surfactant Detergent & Cosmetics

摘　　要：对比了不同构型薄荷醇在定性、定量分析方面的差异性,建立了气相色谱质谱法同时测定化妆品中薄荷醇和薄荷醇乳酸酯,样品经甲醇超声提取,以VF-WAXms(30 m×0.25 mm×0.25μm)色谱柱分离,选择特征离子监测(SIM)扫描模式测定,外标法定量。结果表明,在此实验条件下,不同构型的薄荷醇在响应、保留时间和全扫描质谱图等方面无明显差异。薄荷醇和薄荷醇乳酸酯在0.1~100 mg/L范围内线性良好,相关系数均大于0.999,检出质量浓度分别为0.009和0.002 mg/L,检出限分别为0.9和0.2 mg/kg,定量质量浓度分别为0.027和0.006 mg/L,定量限分别为2.7和0.6 mg/kg,加标回收率为96.3%~100.7%,相对标准偏差为1.9%~3.5%。该方法操作简便,灵敏度高,准确度高,适用于化妆品中薄荷醇和薄荷醇乳酸酯的检测。The differences in qualitative and quantitative analysis between menthol of different configurations were compared.A method for simultaneous determination of menthol and menthyl lactate by GC-MS was established.The injection mode,extraction solvent,extraction time,column,split ratio and other parameters were studied.Samples were ultrasonically extracted by methanol,separated by a VF-WAXms column(30 m×0.25 mm×0.25μm),detected with selected ion monitoring(SIM)scanning mode by direct liquid introduction,and quantified by external standard method.The results show that,there are no significant differences in response,retention time and SCAN mass spectra for menthol with different configurations;the linearity is good for menthol and menthyl lactate in the range of 0.1-100 mg/L,with the correlation coefficient above 0.999;the detection mass concentrations are 0.009 and 0.002 mg/L,the detection limits are 0.9 and 0.2 mg/kg;the quantification mass concentrations are 0.027 and 0.006 mg/L,and the quantification limits are 2.7 and 0.6 mg/kg;the recovery rates of the spiked standards are 96.3%-100.7%with the relative standard deviations of 1.9%-3.5%.Four products(a facial cleanser,two shampoos and a hair conditioner)were tested by this method.This method is simple,sensitive,and accurate,and it is suitable for the determination of menthol and menthyl lactate in cosmetics.

关 键 词：化妆品 薄荷醇 薄荷醇乳酸酯 气相色谱质谱法 

分 类 号：TQ658[化学工程—精细化工]