D-丝氨酸与学习记忆关系的研究进展  

The relationship between D-serine and learning and memory

作　　者：王艳 WANG Yan(Department of Occupational Health and Occupational Medicine,School of Public Health,Shenyang Medical College,Shenyang 110034,China)

机构地区：[1]沈阳医学院公共卫生学院职业卫生与职业医学教研室,辽宁沈阳110034

出　　处：《沈阳医学院学报》2022年第6期561-565,共5页Journal of Shenyang Medical College

基　　金：国家自然科学基金(No.81872570);辽宁省高等学校创新人才支持计划(2020);辽宁省科学技术计划项目(No.2021-MS-347)。

摘　　要：与学习记忆相关的分子机制方面研究较多,其中较为明确的是N-甲基-D-天冬氨酸受体(NMDAR)是学习记忆中极为重要的离子型谷氨酸(Glu)受体,NMDAR激活是神经元网络功能可塑性表达的关键步骤,涉及学习和记忆突触传递过程的长时程增强(LTP)。NMDAR的激活不仅需要Glu,还需其共激动剂D-丝氨酸的参与,当D-丝氨酸与NMDAR的甘氨酸结合位点结合后,Glu才能开放NMDAR偶联的离子通道,发挥其生物学作用。本文对D-丝氨酸与学习记忆关系的研究进展进行简要综述。There are many studies on the molecular mechanisms related to learning and memory,among which the N-methyl D-aspartate receptor(NMDAR)is an extremely important ionic glutamate(Glu)receptor in learning and memory.The activation of NMDAR is a key step in the expression of functional plasticity of neuronal networks,involving long-term potentiation(LTP)of synaptic transmission processes in learning and memory.The activation of NMDAR requires not only Glu,but also its co-agonist D-serine.When D-serine binds to the glycine binding site of NMDAR,Glu can open the NMDAR coupled ion channel and play its biological role.In this review,we summarize recent advances of the relationship between D-serine and learning and memory.

关 键 词：D-丝氨酸 学习记忆 N-甲基-D-天冬氨酸受体 

分 类 号：R994.6[医药卫生—毒理学]