探究初发Graves病患者糖代谢紊乱与甲状腺功能的关系  

To explore the relationship between glucose metabolism disorder and thyroid function in patients with incipient Graves'disease

作　　者：任晨红 李雪锋[2] REN Chenhong;LI Xuefeng(Graduate Training Base,Shiyan Taihe Hospital,Jinzhou Medical University,Shiyan,Hubei 442000,China;Department of Endocrinology,Taihe Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China)

机构地区：[1]锦州医科大学十堰市太和医院研究生培养基地,湖北十堰442000 [2]湖北医药学院附属太和医院内分泌科,湖北十堰442000

出　　处：《中国医学工程》2022年第11期25-28,共4页China Medical Engineering

摘　　要：目的探讨初发毒性弥漫性甲状腺肿(Graves'disease,GD)患者甲状腺功能对糖代谢的影响。方法收集2017年6月至2021年6月期间十堰市太和医院内分泌科收治的358例Graves病初发患者,根据口服葡萄糖耐量试验(OGTT)结果分为糖耐量正常组(A组)、糖耐量异常与空腹血糖受损组(B组)及糖尿病组(C组)。收集各组患者一般资料,完善OGTT、胰岛素释放试验(IRT)、C肽释放试验(CRT)、空腹血糖(FPG)、甲状腺功能等实验室检查,比较相关指标在各组间有无差异。结果GD患者随糖代谢异常程度的加重,平均患病年龄增加,血糖、胰岛素、C肽分泌水平逐步增高,β细胞功能指数(MBCI)降低,差异有统计学意义(P<0.05)。结论初发GD患者可存在胰岛β细胞功能受损与胰岛素抵抗现象,考虑是患者体内的高甲状腺功能状态导致。【Objective】To investigate the effect of thyroid function on glucose metabolism in patients with incipient Graves'disease.【Methods】A total of 358 patients with incipient Graves'disease were enrolled in this study and divided into normal glucose tolerance group(group A),abnormal glucose tolerance and impaired fasting glucose group(group B)and diabetes group(group C)according to oral glucose tolerance test(OGTT).General data of patients in each group were collected,and OGTT,insulin release test(IRT),C-peptide release test(CRT),fasting blood glucose(FPG),thyroid function and other laboratory tests were improved,and the differences in relevant indicators among the groups were compared.【Results】With the increase of abnormal glucose metabolism,the average age of GD patients increased,the secretion levels of glucose,insulin and C-peptide gradually increased,and theβcell function index(MBCI)decreased,the difference was statistically significant(P<0.05).【Conclusion】The function of isletβcells and insulin resistance may be impaired in patients with incipient GD,which is considered to be caused by the high thyroid function status in patients.

关 键 词：GRAVES病 糖代谢 胰岛Β细胞功能 

分 类 号：R581.1[医药卫生—内分泌]