H-FABP、IMA水平与慢性心力衰竭患者心房颤动发生的关系  

Relationship between H-FABP,IMA levels and atrial fibrillation in patients with chronic heart failure

作　　者：陈佩红 胡全 蒲强 CHEN Peihong;HU Quan;PU Qiang(Department of ECG,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China;Department of Gastroenterology,Guizhou International General Hospital,Guiyang 550018,Guizhou,China;Department of Cardiovascular Medicine,Wudang Hospital,Guizhou Medical University,Guiyang 550018,Guizhou,China)

机构地区：[1]贵州医科大学附属医院心电图科,贵州省贵阳市550004 [2]贵黔国际总医院消化内科,贵州省贵阳市550018 [3]贵州医科大学附属乌当医院心血管内科,贵州省贵阳市550001

出　　处：《中南医学科学杂志》2022年第6期861-864,共4页Medical Science Journal of Central South China

基　　金：贵州省卫生健康委科学技术基金项目(gzwkj2022-048)。

摘　　要：目的分析心型脂肪酸结合蛋白(H-FABP)、缺血性修饰白蛋白(IMA)水平与慢性心力衰竭患者心房颤动发生的关系。方法将106例慢性心力衰竭患者根据是否发生心房颤动分为心衰无房颤组58例和心衰房颤组48例。检测并分析两组血清H-FABP、IMA水平。Logistic回归分析影响慢性心力衰竭患者心房颤动发生的因素,并构建慢性心力衰竭患者心房颤动发生风险预测模型列阵图。采用ROC分析H-FABP、IMA水平对慢性心力衰竭患者心房颤动发生的评估价值。结果心衰房颤组血清H-FABP、IMA水平、左心房内径(LAD)及中重度二尖瓣反流比例均大于心衰无房颤组(P<0.05)。Logistic回归分析显示,H-FABP、IMA、中重度二尖瓣反流为慢性心力衰竭患者心房颤动发生的影响因素(P<0.05),列线图模型准确度较好。血清H-FABP、IMA评估慢性心力衰竭患者心房颤动发生的灵敏度分别为83.33%、75.00%,特异度分别为89.66%、87.93%。结论H-FABP、IMA水平与慢性心力衰竭患者发生心房颤动有关,可作为慢性心力衰竭患者心房颤动发生的预测指标。Aim To analyze the relationship between the levels of heart fatty acid binding protein(H-FABP),ischemic modified albumin(IMA)and atrial fibrillation in patients with chronic heart failure.Methods A total of 106 patients with chronic heart failure were divided into heart failure without atrial fibrillation group(n=58)and heart failure with fibrillation group(n=48)according to the ocurrence of atrial fibrillation.The levels of serum H-FABP and IMA in the two groups were detected and analyzed.Logistic regression was used to analyze the factors affecting the occurrence of atrial fibrillation in patients with chronic heart failure,and the risk prediction model array of atrial fibrillation in patients with chronic heart failure was constructed.ROC was used to analyze the value of H-FABP and IMA levels in evaluating the occurrence of atrial fibrillation in patients with chronic heart failure.Results The serum levels of H-FABP,IMA left atrial diameter(LAD),and moderate to severe mitral regurgitation in heart failure with fibrillation group were significantly higher than those in heart failure without atrial fibrillation group(P<0.05).Logistic regression analysis showed that H-FABP,IMA and moderate to severe mitral regurgitation were prognostic factors for atrial fibrillation in patients with chronic heart failure(P<0.05),and the nomogram model had better good accuracy.The sensitivity of serum H-FABP and IMA in evaluating atrial fibrillation in patients with chronic heart failure were 83.33%and 75.00%,and the specificity was 89.66%and 87.93%.Conclusion H-FABP and IMA levels are associated with atrial fibrillation in patients with chronic heart failure,which can be used as predictors of atrial fibrillation in patients with chronic heart failure.

关 键 词：慢性心力衰竭 心房颤动 心型脂肪酸结合蛋白 缺血性修饰白蛋白 

分 类 号：R541.6[医药卫生—心血管疾病]