盐酸丙卡特罗联合孟鲁司特钠治疗儿童支气管哮喘的疗效分析  

Effects of procatol hydrochloride combined with montelukast sodium on symptoms,airway reactivity and inflammatory indexes in children with bronchial asthma

作　　者：耿翠[1] 韩冬梅[1] 张媛媛 GENG Cui;HAN Dongmei;ZHANG Yuanyuan(Department of Pediatrics,Langfang People's Hospital,Langfang 065000,Hebei,China)

机构地区：[1]廊坊市人民医院儿科,河北省廊坊市065000

出　　处：《中南医学科学杂志》2022年第6期918-921,共4页Medical Science Journal of Central South China

基　　金：河北省医学科学研究课题计划项目(20201305)。

摘　　要：目的探讨盐酸丙卡特罗联合孟鲁司特钠对支气管哮喘(BA)患儿疗效的影响。方法80例BA患儿随机分为观察组和对照组各40例。两组患儿入院后均给与吸氧、止咳、化痰、抗感染等常规对症治疗及营养支持。对照组患儿每日睡前口服孟鲁司特钠片,观察组患儿在对照组基础上联合口服盐酸丙卡特罗口服液,共治疗3个月。检测两组患儿治疗前后肺功能指标、炎症指标,采用哮喘生命质量量表(AQLQ)评价生活质量及不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05);治疗后观察组一秒用力呼吸容积(FEV1)、FEV1/用力肺活量、最大呼气峰流速高于对照组(P<0.05);治疗后观察组最大呼气中段流量、50%用力呼气流速(FEF50%)、FEF75%均高于对照组(P<0.05);治疗后观察组血清白细胞介素-6、肿瘤坏死因子-α、免疫球蛋白水平均低于对照组(P<0.05);治疗后观察组AQLQ评分高于对照组(P<0.05)。结论BA患儿采用盐酸丙卡特罗联合孟鲁司特钠治疗可以快速有效缓解临床症状,改善气道反应性和炎症反应损伤,值得临床推广。Aim To investigate the effects of procatelol hydrochloride combined with montelukast sodium on symptoms,airway responsiveness and inflammatory indexes of children with bronchial asthma(BA).Methods 80 children with BA were selected and divided into observation group and control group with 40 cases in each group.After admission,the children in both groups were given oxygen inhalation,cough,phlegm,anti-infection and other conventional symp-tomatic treatment and nutritional support.Children in the control group received montelukast sodium tablets orally before bed every day,and children in the observation group received oral procaterol hydrochloride oral solution together for 3 months.Pulmonary function detector was used to detect pulmonary function indexes[forced vital capacity(FVC),forced respiratory volume in one second(FEV1),maximum peak expiratory flow rate(PEF)]and airway responsiveness indexes(MMEF),50%forced expiratory flow rate(FEF50%),75%forced expiratory flow rate(FEF75)before and after treat-ment%)],inflammatory indexes(serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),immunoglobulin(IgE))were detected before and after treatment in 2 groups.The quality of life was evaluated by asthma quality of life Scale(AQLQ),and the incidence of adverse reactions during treatment was recorded and compared.Results The total effective rate in observation group was significantly higher than that in control group(P<0.05).After treatment,the indexes of FEV1,FEV1/FVC and PEF in observation group were significantly higher than those in control group(P<0.05).After treatment,MMEF,FEF50%and FEF75%in observation group were significantly lower than those in con-trol group(P<0.05);After treatment,the levels of IL-6,TNF-αand IgE in observation group were significantly lower than those in control group(P<0.05).After treatment,AQLQ score of observation group was significantly higher than that of control group(P<0.05).Conclusion The treatment of children with BA with procaterol hydrochloride com-bined with Montelukast sodium

关 键 词：盐酸丙卡特罗 孟鲁司特钠 支气管哮喘 气道反应性 炎症指标 

分 类 号：R725.6[医药卫生—儿科]