黄褐斑不同治疗靶点信号通路研究进展  

Research progress on the signalling pathways for different therapeutic targets of melasma

作　　者：张婷 郭果香[2] 康春义[2] 郝玉琴[2,3] ZHANG Ting;GUO Guoxiang;KANG Chunyi;HAO Yuqin(Graduate School,Inner Mongolia Medical University,Hohhot 010000,Inner Mongolia,China;Department of Dermatology,Inner Mongolia Baogang Hospital,the Third Affiliated Hospital of Inner Mongolia Medical University,Baotou 014010,Inner Mongolia,China;Department of Dermatology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]内蒙古医科大学研究生院,内蒙古自治区呼和浩特市010000 [2]内蒙古包钢医院内蒙古医科大学第三附属医院皮肤性病科,内蒙古自治区包头市014010 [3]北京大学第三医院皮肤科,北京市100191

出　　处：《中南医学科学杂志》2022年第6期945-948,共4页Medical Science Journal of Central South China

基　　金：内蒙古自治区自然科学基金面上项目(2019MS08041)。

摘　　要：黄褐斑是一种多因素作用诱发的慢性色素性皮肤病。黑色素合成活跃及皮损处炎症反应是其主要特点,因此黑色素合成、炎症、氧化应激成为黄褐斑治疗的期望靶点。本文从抑制黑色素合成、抗炎及抗氧化应激方面进行综述。Melasma is a chronic pigmented skin disease induced by multiple factors.Active melanin synthesis and inflammatory response at the lesions are its main features;therefore,melanin synthesis,inflammation,and oxidative stress have become the desired targets for melasma treatment.In this paper,we review in terms of inhibition of melanin synthesis,anti-inflammatory and anti-oxidative stress aspects.

关 键 词：黄褐斑 黑色素 炎症反应 靶点 信号通路 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]