藏红花苷-1和藏红花酸药代动力学及提高生物利用度的研究进展  

Research Progress in Pharmacokinetics and Bioavailability of Crocin-Ⅰand Crocetin

作　　者：王芃 阳志强 郭姿良 刘天龙 王维刚 李晓琳 李茂星 WANG Peng;YANG Zhi-qiang;GUO Zi-liang;LIU Tian-long;WANG Wei-gang;LI Xiao-lin;LI Mao-xing(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China;The 940th Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730000 [2]联勤保障部队第九四〇医院,甘肃兰州2730050

出　　处：《解放军药学学报》2022年第3期223-227,共5页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：甘肃省重点研发项目,蓉栀颗粒提高高原作业效能的作用及临床前研究(20YF3FA035);甘肃省卫生行业科研计划项目,藏红花苷(Crocin)抗缺氧抗疲劳作用及机制研究(GSWSKY2020-41);中央高校基本科研业务费专项资金项目,藏药现代化研究与开发创新团队(31920200010);拔尖培育项目(2021yxky001)。

摘　　要：藏红花苷-1具有多种药理活性,主要存在于鸢尾科植物番红花(Crocus sativus Linnaeus)柱头和茜草科植物栀子(Gardenia jasminoides Ellis)果实中。口服用药后,藏红花苷-1只有小部分能直接进入体内,大部分被分解成藏红花酸或藏红花酸单(双)糖醛酸形式被机体吸收利用;藏红花酸则能直接通过肠道内壁,进入机体后分布到心、肝、肾和肺等脏器组织中。目前可利用结构改造和新型制剂工艺,提高藏红花苷-1和藏红花酸的生物利用度、生物活性和半衰期。本文综述藏红花苷-1和藏红花酸近几年研究结果,为其临床开发利用提供科学依据和参考。Crocin-Ⅰ,which possesses various pharmacological activities,is known to exist in the desiccative ripe fruit of Gardenia jasminoides Ellis of the Rubiaceae family,and in the stigmas of Crocus sativus Linnaeus of the Iridaceae family.After oral administration of crocin-Ⅰand crocetin,the absorption sites are mostly located in the intestinal tract,and only a small fraction of crocin-Ⅰcan enter the body as a prototype so that most of it is decomposed into crocetin or crocetin uronic acid,which is absorbed by the body.However,crocetin can directly pass through the intestinal wall,enter the body and come to be distributed to the tissues of the heart,liver,kidney and lung.New formulation technology and structural modification of crocin-Ⅰand crocetin can be used to improve their bioavailability,bioactivity,and half-life.This paper summarizes the recent findings of literature research on crocin-Ⅰand crocetin in order to provide reference for their clinical development and utilization.

关 键 词：藏红花苷-1 藏红花酸 药代动力学 生物利用度 

分 类 号：R969.1[医药卫生—药理学]