化学-酶法串联一锅合成R-γ-氨基酸  

Chemoenzymatic Synthesis of R-γ-Amino Acid in One Pot

作　　者：杨鹏[1] 程熹 吴星均 朱虹旭 刘雪粉[1] 杨华云[1] 许可 YANG Peng;CHENG Xi;WU Xingjun;ZHU Hongxu;LIU Xuefen;YANG Huayun;XU Ke(Qianjiang College,Hangzhou Normal University,Hangzhou 310036,China;Zhejiang Titan Design&Engineering Co.,Ltd.,Hangzhou 310030,China)

机构地区：[1]杭州师范大学钱江学院,浙江杭州310036 [2]浙江省天正设计工程有限公司,浙江杭州310030

出　　处：《杭州师范大学学报（自然科学版）》2022年第6期567-570,577,共5页Journal of Hangzhou Normal University(Natural Science Edition)

基　　金：浙江省自然科学基金项目(LGF22B070001)。

摘　　要：为开发简易高效的手性γ-氨基酸合成方法,采用烯丙基胺作为起始底物,在脂肪酶催化下利用酯化动态动力学拆分得到光学纯的烯丙基酰胺,再与α,β-不饱和酸进行一锅烯烃复分解反应制得相应的手性γ-氨基酸.To develop the convenient and efficient synthesis strategy of chiral γ-amino acids, allylamine was adopted as the starting substrate and the lipase-catalyzed dynamic kinetic resolution was utilized to obtain optical pure allyl-amid. Then, the optical pure allyl-amid reacted with α, β-unsaturated acid to form the chiral γ-amino acids in one pot.

关 键 词：酶促动态动力学拆分 烯烃复分解反应 手性γ-氨基酸 

分 类 号：O625.5[理学—有机化学]