New flavanone-monoterpene hybrids as α-glucosidase inhibitors from the root bark of Morus alba  

作　　者：Lin-Lin Tian Hua Zhang 

机构地区：[1]School of Biological Science and Technology,University of Jinan,Jinan 250022,China

出　　处：《TMR Modern Herbal Medicine》2022年第4期37-41,共5页TMR现代中药

基　　金：Financial support is from the Natural Science Foundation of Shandong Province for Distinguished Young Scholars(No.JQ201721).

摘　　要：Objective The Morus alba root bark is a well-known Chinese herbal medicine called Sang-Bai-Pi and has often been used to relieve the hyperglycemic symptom of diabetes patients.The current work aims to further explore its bioactive constituents with α-glucosidase inhibitory activity for the potential treatment of diabetes.Methods A combination of different separating techniques including routine column chromatograph and HPLC especially on chiral columns were applied for the isolation of target molecules,while comprehensive spectroscopic experiments comprising MS,NMR,ECD,etc.were carried out to complete the structural assignment.The anti-hyperglycemic property of the isolates was evaluated by an in vitro α-glucosidase inhibitory bioassay.Results Two pairs of new flavanone-monoterpene hybrid enantiomers were isolated and identified,and an interesting phenomenon of mutual transformation between these cometabolites were detected,which resulted in their regio-isomerization and enantiomerization.The bioassay results revealed remarkable α-glucosidase inhibitory activity for these fascinating molecules.Conclusions The Morus alba root bark is a rich source of bioactive flavonoid derivatives and deserves further investigations to develop new potential chemotherapies for diabetes control and treatment.

关 键 词：Morus alba Flavanone Regio-isomerization ENANTIOMERIZATION α-Glucosidase inhibition 

分 类 号：R284[医药卫生—中药学]