右心室-肺动脉耦合在肺动脉高压中的应用进展  

Right Ventricular-pulmonary Arterial Coupling in Pulmonary Hypertension:Application Advances

作　　者：段安琪 罗勤 赵智慧 赵青 柳志红[1] DUAN Anqi;LUO Qin;ZHAO Zhihui;ZHAO Qing;LIU Zhihong(Center for Pulmonary Vascular Disease,Fuwai Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,National Center for Cardiovascular Disease,Beijing 100037,China)

机构地区：[1]国家心血管病中心,中国医学科学院阜外医院肺血管病中心,北京100037

出　　处：《协和医学杂志》2022年第6期1051-1056,共6页Medical Journal of Peking Union Medical College Hospital

基　　金：中国医学科学院临床与转化医学研究基金(2020-I2M-C&T-B-055);北京市自然科学基金(7202168)。

摘　　要：肺动脉高压患者的临床预后与右心功能密切相关。病变早期,右心室可通过增加收缩力的方式维持肺循环正常血供,随病情进展,右心室后负荷持续升高,右心室逐渐失代偿,甚至发生右心衰竭。右心室-肺动脉耦合是指右心室收缩力与后负荷之间的匹配关系,耦合受损可作为右心室功能障碍的早期标志。本文就右心室-肺动脉耦合的评估方法及其在肺动脉高压中的应用进展作一综述,以期为临床诊疗提供参考。Prognosis in pulmonary hypertension is closely associated with right heart function.In the early stage of pulmonary hypertension,the right ventricle can maintain the normal blood flow of the pulmonary circulation by increasing its contractility.As the disease progresses,the right ventricular afterload rises persistently,the right ventricle is gradually decompensated,even right heart failure occurs.Right ventricular-pulmonary arterial coupling refers to a matching between right ventricular contractility and afterload.The impairment of this coupling may be an early marker of right ventricular dysfunction.This article reviews the research progress of its assessment and application in pulmonary hypertension.

关 键 词：肺动脉高压 右心室功能障碍 超声心动图 右心室-肺动脉耦合 

分 类 号：R543.2[医药卫生—心血管疾病]