炎症反应在冠状动脉微血管疾病中的研究进展  

Recent Advances in the Pathogenesis of Coronary Microvascular Disease:The role of Inflammatory Reactions

作　　者：曹俊 秦晋梅 薛伟珍[2] CAO Jun;QIN Jinmei;XUE Weizhen(Shanxi Medical University,Taiyuan 030000,China;Department of Cardiology,Taiyuan Central Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,太原030000 [2]山西医科大学附属太原中心医院心血管内科,太原030001

出　　处：《协和医学杂志》2022年第6期1057-1063,共7页Medical Journal of Peking Union Medical College Hospital

基　　金：山西省卫生健康委科研项目(2017140)。

摘　　要：冠状动脉微血管疾病(coronary microvascular disease,CMVD)是非阻塞性冠状动脉病变患者心肌缺血的主要原因,由于起病隐匿、病因复杂,目前对其病理生理机制尚缺乏全面认识,极大地限制了其临床诊断与治疗。冠状动脉微血管内皮细胞损伤是诱发CMVD的核心,多种炎症因子可通过内皮细胞损伤途径参与CMVD病情进展。本文主要对炎症反应在CMVD中的可能作用机制作一综述,以期为CMVD的诊断、治疗及预防提供参考。Coronary microvascular disease(CMVD)is the main cause of myocardial ischemia in patients with non-obstructive coronary artery disease.However,there is still a lack of comprehensive understanding of its pathophysiological mechanism due to the hidden pathogenesis and complex etiologies,which greatly restricts its clinical diagnosis and treatment.The injury of coronary artery microvascular endothelial cells is central to the induction of CMVD,and various inflammatory factors can participate in the pathogenesis of CMVD through the endothelial cell injury pathway.This article mainly reviews the possible mechanisms of inflammatory response in CMVD,in the hope of providing reference for the diagnosis,treatment and prevention of CMVD.

关 键 词：冠状动脉微血管疾病 炎症反应 内皮细胞损伤 

分 类 号：R543.31[医药卫生—心血管疾病]