妇科疾病患者梅毒血清学试验检测结果分析  

Analysis of syphilis serological test results in gynecological inpatients

作　　者：孙跃华 王卓 于晓黎 王宝岩 孙静莉 牛军 张晓东 Sun Yuehua;Wang Zhuo;Yu Xiaoli;Wang Baoyan;Sun Jingli;Niu Jun;Zhang Xiaodong(Department of Dermatology,General Hospital of Northern Theater Command,Shenyang 110016,China;Department of Clinical Laboratory,General Hospital of Northern Theater Command,Shenyang 110016,China;Medical Security Centre Information Section,General Hospital of Northern Theater Command,Shenyang 110016,China;Department of Obstetrics and gynecology,General Hospital of Northern Theater Command,Shenyang 110016,China)

机构地区：[1]北部战区总医院皮肤科,沈阳110016 [2]北部战区总医院临床试验研究室,沈阳110016 [3]北部战区总医院医疗保障中心信息科,沈阳110016 [4]北部战区总医院妇产科,沈阳110016

出　　处：《中国临床实用医学》2022年第4期38-41,共4页China Clinical Practical Medicine

基　　金：辽宁省科学技术计划项目(2021JH2/10300096)。

摘　　要：目的分析梅毒在妇科疾病中的感染情况。方法本研究为回顾性研究, 选取1999年6月至2019年6月北部战区总医院妇科收治的41 144例患有妇科疾病患者的临床资料, 年龄(33.52±15.13)岁, 年龄范围为6~91岁。所有患者血清标本经梅毒螺旋体抗体试验(TPPA)和快速血浆反应素试验(RPR)检测, 对妇科疾病的梅毒感染情况进行统计分析。结果梅毒血清抗体(TPPA、RPR)阳性患者116例。每5年梅毒血清学抗体阳性检出率比较, 差异无统计学意义(P>0.05)。一、二期梅毒34例, 隐性梅毒82例。一、二期梅毒与隐性梅毒患者的年龄、RPR滴度间比较, 差异均有统计学意义(P<0.05)。将116例阳性患者按妇科疾病发病机制和损伤特点分为异位妊娠、引产和流产、子宫(颈)肿瘤、卵巢(输卵管)肿瘤、妇科炎症和其他6类疾病, 前两者疾病构成比较高(41.4%);6类妇科疾病患者的年龄、RPR滴度比较, 差异均有统计学意义(P<0.05)。结论梅毒对妇科疾病的发生发展具有一定的影响, 导致生育期妇女出现异位妊娠、引产和流产, 住院妇科患者隐性梅毒占比较高。Objective To analyze the infection of syphilis in gynecological diseases.Methods This study was a retrospective study,and the clinical data of 41144 patients with gynecological diseases,aged(33.52±15.13)years old,ranging from 6 to 91 years old,admitted to The General Hospital of the Northern Theater Command from June 1999 to June 2019 were selected.Serum samples of all patients were tested by treponema pallidum antibody test(TPPA)and rapid plasma reaction-hormone test(RPR),and the syphilis infection of gynecological diseases were statistically analyzed.Results There were 116 patients with positive syphilis serum antibody.There was no significant difference in the positive detection rate of syphilis serology every five years(P>0.05).There were 34 cases of primary and secondary syphilis and 82 cases of latent syphilis.There were significant differences in the age and RPR titer between primary and secondary and latent syphilis(P<0.05).Patients with positive syphilis serum antibody detection were divided into 6 kinds of diseases including ectopic pregnancy,induced abortion,uterine(cervical)tumor,ovarian(tubal)tumor,gynecological inflammation and the other.They are divided according to the pathogenesis characteristics of gynecological diseases.Ectopic pregnancy and induced abortion constitute a relatively high proportion(41.4%).There were significant differences in the average age and RPR titer among the six types of gynecological diseases(P<0.05).Conclusions Syphilis has a certain influence on the occurrence and development of gynecological diseases,which can cause ectopic pregnancy and induced abortion in women in their reproductive period.Recessive syphilis accounts for a relatively high proportion of hospitalized gynecological patients.

关 键 词：梅毒 血清学检测 妇科疾病 患病率 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]